The article "Research Progress in Skin Aging and Immunity" by Xin He, Xinyu Gao, and Weidong Xie provides a comprehensive overview of the complex relationship between skin aging and the immune system. Skin aging is characterized by structural and functional changes, including reduced collagen content, decreased skin thickness, dryness, and the formation of wrinkles. These changes are underpinned by multiple mechanisms such as the free radical theory, inflammation theory, photoaging theory, and metabolic theory. The skin immune system, comprising macrophages, lymphocytes, dendritic cells, and mast cells, plays a crucial role in maintaining skin homeostasis and responding to injury or infection. As age advances, these immune cells may undergo senescence or accelerated aging, leading to reduced cell division capability, increased mortality, altered gene expression patterns, and changes in immune cell functions. These changes collectively impact the overall function of the immune system, affecting skin health and aging. The article discusses the characteristics of skin aging, the composition and function of the skin immune system, the aging of immune cells, and the effects of these cells on immune function and skin aging. It highlights that immune dysfunction plays a significant role in skin aging, suggesting that immunoregulation may become an important strategy for the prevention and treatment of skin aging. The review also explores the impact of various internal and external factors on skin aging, including genetic factors, environmental stressors, and lifestyle choices. Finally, it outlines strategies for enhancing skin immune cell function and inhibiting immune cell over-activation to combat skin aging, emphasizing the potential of natural products and physiological active factors in this context.The article "Research Progress in Skin Aging and Immunity" by Xin He, Xinyu Gao, and Weidong Xie provides a comprehensive overview of the complex relationship between skin aging and the immune system. Skin aging is characterized by structural and functional changes, including reduced collagen content, decreased skin thickness, dryness, and the formation of wrinkles. These changes are underpinned by multiple mechanisms such as the free radical theory, inflammation theory, photoaging theory, and metabolic theory. The skin immune system, comprising macrophages, lymphocytes, dendritic cells, and mast cells, plays a crucial role in maintaining skin homeostasis and responding to injury or infection. As age advances, these immune cells may undergo senescence or accelerated aging, leading to reduced cell division capability, increased mortality, altered gene expression patterns, and changes in immune cell functions. These changes collectively impact the overall function of the immune system, affecting skin health and aging. The article discusses the characteristics of skin aging, the composition and function of the skin immune system, the aging of immune cells, and the effects of these cells on immune function and skin aging. It highlights that immune dysfunction plays a significant role in skin aging, suggesting that immunoregulation may become an important strategy for the prevention and treatment of skin aging. The review also explores the impact of various internal and external factors on skin aging, including genetic factors, environmental stressors, and lifestyle choices. Finally, it outlines strategies for enhancing skin immune cell function and inhibiting immune cell over-activation to combat skin aging, emphasizing the potential of natural products and physiological active factors in this context.