Skin aging is a complex process involving structural and functional changes, characterized by reduced collagen content, decreased skin thickness, dryness, and wrinkle formation. It is influenced by multiple mechanisms, including the free radical theory, inflammation theory, photoaging theory, and metabolic theory. The skin immune system, a critical part of the body's defense mechanism, includes macrophages, lymphocytes, dendritic cells, and mast cells, which maintain skin homeostasis and respond to injury or infection. As age advances, immune cells may undergo senescence or accelerated aging, leading to reduced cell division, increased mortality, altered gene expression, and impaired immune function. These changes impact the overall immune system function and contribute to skin aging. The skin immune system plays a vital role in maintaining skin homeostasis and effective wound healing. Immune dysfunction is a significant factor in skin aging, suggesting that immunoregulation could be an important strategy for preventing and treating skin aging. The aging of skin immune cells, including macrophages, T cells, and dendritic cells, leads to functional decline, affecting the skin's ability to clear senescent cells and defend against infections. Inflammatory responses, such as those involving IL-17, exacerbate skin aging by promoting oxidative stress and chronic inflammation. Environmental factors like ultraviolet radiation, air pollution, and smoking also contribute to skin aging by causing oxidative damage and impairing immune function. Strategies to combat skin aging include enhancing immune cell function, inhibiting immune over-activation, and using products that reduce inflammation. Vitamin D3 and melatonin are important in regulating immune function and skin health. Anti-inflammatory products and immune-regulating therapies are promising approaches to improve skin health and delay aging. Understanding the complex relationship between skin aging and immunity is crucial for developing effective anti-aging strategies. Future research should focus on elucidating the molecular and cellular mechanisms of skin immune aging and developing targeted therapies to improve skin health and quality of life.Skin aging is a complex process involving structural and functional changes, characterized by reduced collagen content, decreased skin thickness, dryness, and wrinkle formation. It is influenced by multiple mechanisms, including the free radical theory, inflammation theory, photoaging theory, and metabolic theory. The skin immune system, a critical part of the body's defense mechanism, includes macrophages, lymphocytes, dendritic cells, and mast cells, which maintain skin homeostasis and respond to injury or infection. As age advances, immune cells may undergo senescence or accelerated aging, leading to reduced cell division, increased mortality, altered gene expression, and impaired immune function. These changes impact the overall immune system function and contribute to skin aging. The skin immune system plays a vital role in maintaining skin homeostasis and effective wound healing. Immune dysfunction is a significant factor in skin aging, suggesting that immunoregulation could be an important strategy for preventing and treating skin aging. The aging of skin immune cells, including macrophages, T cells, and dendritic cells, leads to functional decline, affecting the skin's ability to clear senescent cells and defend against infections. Inflammatory responses, such as those involving IL-17, exacerbate skin aging by promoting oxidative stress and chronic inflammation. Environmental factors like ultraviolet radiation, air pollution, and smoking also contribute to skin aging by causing oxidative damage and impairing immune function. Strategies to combat skin aging include enhancing immune cell function, inhibiting immune over-activation, and using products that reduce inflammation. Vitamin D3 and melatonin are important in regulating immune function and skin health. Anti-inflammatory products and immune-regulating therapies are promising approaches to improve skin health and delay aging. Understanding the complex relationship between skin aging and immunity is crucial for developing effective anti-aging strategies. Future research should focus on elucidating the molecular and cellular mechanisms of skin immune aging and developing targeted therapies to improve skin health and quality of life.