The article reviews the research progress on post-acute sequelae after SARS-CoV-2 infection (PASC), also known as "long COVID," which affects multiple organ systems and can persist for months or years. PASC includes various physical and neuropsychiatric symptoms, such as fatigue, muscle pain, cognitive impairment, and psychiatric disorders. The pathophysiological mechanisms of PASC are multifaceted, involving persistent low-load virus, abnormal immune responses, secondary autoimmune diseases, and multisystem damage caused by microthrombosis. The article highlights the importance of early rehabilitation measures, including pulmonary rehabilitation, to improve lung function and quality of life in patients with PASC. It also discusses the impact of PASC on the respiratory, cardiovascular, neurological, psychiatric, urinary, blood, skin, and digestive systems, emphasizing the need for long-term follow-up and management strategies to address these complications.The article reviews the research progress on post-acute sequelae after SARS-CoV-2 infection (PASC), also known as "long COVID," which affects multiple organ systems and can persist for months or years. PASC includes various physical and neuropsychiatric symptoms, such as fatigue, muscle pain, cognitive impairment, and psychiatric disorders. The pathophysiological mechanisms of PASC are multifaceted, involving persistent low-load virus, abnormal immune responses, secondary autoimmune diseases, and multisystem damage caused by microthrombosis. The article highlights the importance of early rehabilitation measures, including pulmonary rehabilitation, to improve lung function and quality of life in patients with PASC. It also discusses the impact of PASC on the respiratory, cardiovascular, neurological, psychiatric, urinary, blood, skin, and digestive systems, emphasizing the need for long-term follow-up and management strategies to address these complications.