This paper, presented by a multidisciplinary panel at the 2013 meeting of the International Society for Traumatic Stress Studies, addresses key questions in the field of resilience research. The panelists—Drs. Steven Southwick, George Bonanno, Ann Masten, Catherine Panter-Brick, and Rachel Yehuda— discuss the definition of resilience, its determinants, the role of new technologies, and effective ways to enhance resilience. They agree that resilience is a complex construct, varying across individuals, families, organizations, and societies. Determinants of resilience include genetic, epigenetic, developmental, demographic, cultural, economic, and social factors. The panel emphasizes the need for a multi-level analysis approach to study resilience and highlights the importance of integrating resilience into various fields of medicine, mental health, and science. They also explore the concept of resilience as a stable trajectory of healthy functioning, a process of harnessing resources to sustain well-being, and the role of technology in understanding and enhancing resilience. The discussion underscores the importance of empirical research and the potential for building resilience through various interventions.This paper, presented by a multidisciplinary panel at the 2013 meeting of the International Society for Traumatic Stress Studies, addresses key questions in the field of resilience research. The panelists—Drs. Steven Southwick, George Bonanno, Ann Masten, Catherine Panter-Brick, and Rachel Yehuda— discuss the definition of resilience, its determinants, the role of new technologies, and effective ways to enhance resilience. They agree that resilience is a complex construct, varying across individuals, families, organizations, and societies. Determinants of resilience include genetic, epigenetic, developmental, demographic, cultural, economic, and social factors. The panel emphasizes the need for a multi-level analysis approach to study resilience and highlights the importance of integrating resilience into various fields of medicine, mental health, and science. They also explore the concept of resilience as a stable trajectory of healthy functioning, a process of harnessing resources to sustain well-being, and the role of technology in understanding and enhancing resilience. The discussion underscores the importance of empirical research and the potential for building resilience through various interventions.