The article reviews the resistance plasmid families in Enterobacteriaceae, focusing on their classification, distribution, and the emergence of multidrug-resistant strains. Plasmids are defined as autonomous genetic elements capable of replication and can confer resistance to various antibiotics. The classification of plasmids is based on their phylogenetic relatedness and stability during conjugation, with 27 Inc groups recognized in Enterobacteriaceae. The IncF, IncA/C, IncL/M, and IncI1 plasmids are the most prevalent and associated with specific resistance genes. These plasmids are linked to positive selection pressure from antimicrobial use, though the IncF family is common in natural fecal flora. The article highlights the spread of CTX-M and other extended-spectrum β-lactamase (ESBL) genes on IncF plasmids, particularly in human and animal sources. It also discusses the dissemination of AmpC β-lactamase genes, carbapenem-hydrolyzing oxacillinases, and quinolone resistance genes on various plasmid families. The diversity and prevalence of these plasmids suggest that they play a significant role in the evolution and spread of antimicrobial resistance in Enterobacteriaceae. The article concludes by discussing the potential of targeting specific plasmid families as a therapeutic strategy against drug-resistant bacteria.The article reviews the resistance plasmid families in Enterobacteriaceae, focusing on their classification, distribution, and the emergence of multidrug-resistant strains. Plasmids are defined as autonomous genetic elements capable of replication and can confer resistance to various antibiotics. The classification of plasmids is based on their phylogenetic relatedness and stability during conjugation, with 27 Inc groups recognized in Enterobacteriaceae. The IncF, IncA/C, IncL/M, and IncI1 plasmids are the most prevalent and associated with specific resistance genes. These plasmids are linked to positive selection pressure from antimicrobial use, though the IncF family is common in natural fecal flora. The article highlights the spread of CTX-M and other extended-spectrum β-lactamase (ESBL) genes on IncF plasmids, particularly in human and animal sources. It also discusses the dissemination of AmpC β-lactamase genes, carbapenem-hydrolyzing oxacillinases, and quinolone resistance genes on various plasmid families. The diversity and prevalence of these plasmids suggest that they play a significant role in the evolution and spread of antimicrobial resistance in Enterobacteriaceae. The article concludes by discussing the potential of targeting specific plasmid families as a therapeutic strategy against drug-resistant bacteria.