Piezoelectric polymers play a crucial role in nerve regeneration, as highlighted in this review. The article discusses the use of piezoelectric materials, such as polyvinylidene difluoride (PVDF), poly(l-lactic acid) (PLLA), and poly(3-hydroxybutyrate) (PHB), in neural tissue engineering. These materials are biocompatible, biodegradable, and capable of generating piezoelectric charges, which can stimulate nerve regeneration. The review outlines the design of optimal nerve scaffolds, the mechanisms of nerve regeneration via piezoelectric stimulation, and the application of various piezoelectric polymers in nerve guidance conduits. It also examines the advantages and challenges of using piezoelectric materials in nerve repair, including their ability to provide electrical stimuli without external power sources or electrodes. The review emphasizes the importance of piezoelectricity in promoting nerve regeneration, as it can enhance axonal growth, myelination, and functional recovery. The study also discusses the potential of magnetoelectric materials in combination with alternating magnetic fields for nerve repair, as they can provide controlled and reproducible cyclic deformations. The review highlights the need for further research to optimize the use of piezoelectric materials in nerve regeneration, including the development of more effective scaffolds and the understanding of the underlying mechanisms of piezoelectric stimulation. Overall, the review provides a comprehensive overview of the current state of research on piezoelectric polymers in neural tissue engineering and their potential applications in nerve repair.Piezoelectric polymers play a crucial role in nerve regeneration, as highlighted in this review. The article discusses the use of piezoelectric materials, such as polyvinylidene difluoride (PVDF), poly(l-lactic acid) (PLLA), and poly(3-hydroxybutyrate) (PHB), in neural tissue engineering. These materials are biocompatible, biodegradable, and capable of generating piezoelectric charges, which can stimulate nerve regeneration. The review outlines the design of optimal nerve scaffolds, the mechanisms of nerve regeneration via piezoelectric stimulation, and the application of various piezoelectric polymers in nerve guidance conduits. It also examines the advantages and challenges of using piezoelectric materials in nerve repair, including their ability to provide electrical stimuli without external power sources or electrodes. The review emphasizes the importance of piezoelectricity in promoting nerve regeneration, as it can enhance axonal growth, myelination, and functional recovery. The study also discusses the potential of magnetoelectric materials in combination with alternating magnetic fields for nerve repair, as they can provide controlled and reproducible cyclic deformations. The review highlights the need for further research to optimize the use of piezoelectric materials in nerve regeneration, including the development of more effective scaffolds and the understanding of the underlying mechanisms of piezoelectric stimulation. Overall, the review provides a comprehensive overview of the current state of research on piezoelectric polymers in neural tissue engineering and their potential applications in nerve repair.