Salmonella Dublin is a Gram-negative bacterium that is host-adapted to cattle and has increased prevalence in dairy facilities. It can cause severe disease in young calves and reduce the performance of mature animals, leading to high morbidity and mortality. S. Dublin is a zoonotic pathogen that can be lethal to humans and is resistant to multiple antibiotics, making it difficult to control and eradicate. This review discusses the prevalence of S. Dublin in dairy farms, risk factors for infection, and current strategies for prevention and control. It also highlights the economic impact of the disease and the importance of identifying and managing latent carriers. S. Dublin is a significant threat to both animal and human health, and its control is essential to prevent outbreaks and reduce the risk of infection in farm workers and consumers. The review emphasizes the need for improved management practices, including sanitation, proper handling of colostrum and milk, and the isolation of sick animals, to prevent the spread of S. Dublin in dairy herds.Salmonella Dublin is a Gram-negative bacterium that is host-adapted to cattle and has increased prevalence in dairy facilities. It can cause severe disease in young calves and reduce the performance of mature animals, leading to high morbidity and mortality. S. Dublin is a zoonotic pathogen that can be lethal to humans and is resistant to multiple antibiotics, making it difficult to control and eradicate. This review discusses the prevalence of S. Dublin in dairy farms, risk factors for infection, and current strategies for prevention and control. It also highlights the economic impact of the disease and the importance of identifying and managing latent carriers. S. Dublin is a significant threat to both animal and human health, and its control is essential to prevent outbreaks and reduce the risk of infection in farm workers and consumers. The review emphasizes the need for improved management practices, including sanitation, proper handling of colostrum and milk, and the isolation of sick animals, to prevent the spread of S. Dublin in dairy herds.