This research paper explores best practices in management and leadership for healthcare quality improvement. It emphasizes the critical role of effective leadership, particularly transformational leadership, in driving successful quality improvement initiatives. The study highlights the importance of interdisciplinary collaboration, ethical considerations, and technological integration. Key findings underscore the significance of patient-centric approaches and the need for enhanced training programs. Implications for healthcare practice and policy include prioritizing ongoing leadership education, integrating patient perspectives, and strategically investing in technology. The research underscores the interconnectedness of these elements in driving successful quality improvement initiatives, contributing to improved patient outcomes and enhanced healthcare delivery.This research paper explores best practices in management and leadership for healthcare quality improvement. It emphasizes the critical role of effective leadership, particularly transformational leadership, in driving successful quality improvement initiatives. The study highlights the importance of interdisciplinary collaboration, ethical considerations, and technological integration. Key findings underscore the significance of patient-centric approaches and the need for enhanced training programs. Implications for healthcare practice and policy include prioritizing ongoing leadership education, integrating patient perspectives, and strategically investing in technology. The research underscores the interconnectedness of these elements in driving successful quality improvement initiatives, contributing to improved patient outcomes and enhanced healthcare delivery.