This review discusses the advancements in immune research using organoid-based co-culture and chip systems. Organoids, self-renewing 3D cellular structures derived from stem cells, have emerged as powerful tools for studying the complex interactions between immune cells and epithelial cells in both healthy and pathological conditions. The review highlights how organoid-based immune cell co-culture experiments can advance disease modeling of cancer, inflammatory bowel disease, and tuberculosis. It also emphasizes the benefits of microfluidics-based technologies for high-throughput, scalable, and reproducible results. Additionally, the review explores the potential of genome editing techniques and patient-derived organoids in improving disease modeling and facilitating precision medicine. The authors advocate for the development of novel infrastructures such as organoid biobanks and facilities to support these efforts. Finally, the review discusses the future perspectives of organoid technology in disease modeling, personalized therapy development, and drug screening, emphasizing the need for collaborative efforts and technological advancements to fully realize its potential.This review discusses the advancements in immune research using organoid-based co-culture and chip systems. Organoids, self-renewing 3D cellular structures derived from stem cells, have emerged as powerful tools for studying the complex interactions between immune cells and epithelial cells in both healthy and pathological conditions. The review highlights how organoid-based immune cell co-culture experiments can advance disease modeling of cancer, inflammatory bowel disease, and tuberculosis. It also emphasizes the benefits of microfluidics-based technologies for high-throughput, scalable, and reproducible results. Additionally, the review explores the potential of genome editing techniques and patient-derived organoids in improving disease modeling and facilitating precision medicine. The authors advocate for the development of novel infrastructures such as organoid biobanks and facilities to support these efforts. Finally, the review discusses the future perspectives of organoid technology in disease modeling, personalized therapy development, and drug screening, emphasizing the need for collaborative efforts and technological advancements to fully realize its potential.