The article discusses the management of cytokine-related toxicities associated with chimeric antigen receptor T-cell (CAR-T) therapy. CAR-T therapy has revolutionized cancer treatment, but it can cause severe toxicities such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS). These toxicities are characterized by cytokine storms and hyperinflammation, but they differ in their underlying mechanisms. The article summarizes current understanding of these toxicities, their management, and emerging therapies. It highlights that many of these agents do not affect CAR-T's anti-tumor function, allowing for broader applications. The article also discusses the biology of these toxicities, their predictors, and the various treatment options available. It emphasizes the importance of understanding the underlying mechanisms to improve toxicity management and prevention. The article concludes that further research is needed to better understand the differences between these toxicities and to develop more effective treatments.The article discusses the management of cytokine-related toxicities associated with chimeric antigen receptor T-cell (CAR-T) therapy. CAR-T therapy has revolutionized cancer treatment, but it can cause severe toxicities such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS). These toxicities are characterized by cytokine storms and hyperinflammation, but they differ in their underlying mechanisms. The article summarizes current understanding of these toxicities, their management, and emerging therapies. It highlights that many of these agents do not affect CAR-T's anti-tumor function, allowing for broader applications. The article also discusses the biology of these toxicities, their predictors, and the various treatment options available. It emphasizes the importance of understanding the underlying mechanisms to improve toxicity management and prevention. The article concludes that further research is needed to better understand the differences between these toxicities and to develop more effective treatments.