The study by Wajnberg et al. investigates the robustness, functionality, and longevity of antibody responses to SARS-CoV-2 in individuals with mild-to-moderate COVID-19. Based on a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, the researchers found that the majority of infected individuals experienced robust immunoglobulin G (IgG) antibody responses against the viral spike protein. Titers of anti-spike binding antibodies were relatively stable for at least 5 months and significantly correlated with neutralization of authentic SARS-CoV-2. Over 90% of seroconverters showed detectable neutralizing antibody responses, which remained stable for several months after infection. The study also assessed the stability of antibody titers over time, finding only modest declines at the 5-month mark. These findings suggest that the antibody responses to SARS-CoV-2 are robust and may provide protection against reinfection, although further studies are needed to establish a correlate of protection.The study by Wajnberg et al. investigates the robustness, functionality, and longevity of antibody responses to SARS-CoV-2 in individuals with mild-to-moderate COVID-19. Based on a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, the researchers found that the majority of infected individuals experienced robust immunoglobulin G (IgG) antibody responses against the viral spike protein. Titers of anti-spike binding antibodies were relatively stable for at least 5 months and significantly correlated with neutralization of authentic SARS-CoV-2. Over 90% of seroconverters showed detectable neutralizing antibody responses, which remained stable for several months after infection. The study also assessed the stability of antibody titers over time, finding only modest declines at the 5-month mark. These findings suggest that the antibody responses to SARS-CoV-2 are robust and may provide protection against reinfection, although further studies are needed to establish a correlate of protection.