Folate, a water-soluble B vitamin, is essential for nucleic acid and protein synthesis and is involved in DNA repair, epigenetic regulation, and one-carbon (1C) metabolism. Folate deficiency, caused by low dietary intake, poor absorption, or genetic defects, increases the risk of liver diseases such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic liver disease (ALD), viral hepatitis, liver fibrosis, and liver cancer. Folate deficiency leads to hyperhomocysteinemia, which increases the risk of hypertension and cardiovascular disease, and high homocysteine levels are an independent risk factor for liver fibrosis and cirrhosis. Folate deficiency also impairs lipid metabolism in the liver, leading to lipid accumulation and fibrosis. Folate is involved in the methionine cycle, DNA synthesis, and epigenetic regulation, and its deficiency contributes to liver disease progression. Folate deficiency affects liver homeostasis, lipid metabolism, and gene expression, and is associated with increased liver fibrosis and cirrhosis. Folate deficiency is linked to reduced serum folate levels in patients with chronic hepatitis and cirrhosis. Folate deficiency increases the secretion of pro-inflammatory factors and impairs lipid metabolism, leading to liver damage. Folate deficiency is also associated with reduced DNA methylation and altered gene expression in liver diseases. Folate deficiency may promote the development of liver diseases by impairing 1C metabolism and methionine metabolism. Folate deficiency is associated with increased liver fibrosis and cirrhosis, and folate supplementation may help reduce liver damage and improve liver function. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with increased liver fibrosis and cirrhosis, and folate supplementation may help reduce liver damage and improve liver function. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases.Folate, a water-soluble B vitamin, is essential for nucleic acid and protein synthesis and is involved in DNA repair, epigenetic regulation, and one-carbon (1C) metabolism. Folate deficiency, caused by low dietary intake, poor absorption, or genetic defects, increases the risk of liver diseases such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic liver disease (ALD), viral hepatitis, liver fibrosis, and liver cancer. Folate deficiency leads to hyperhomocysteinemia, which increases the risk of hypertension and cardiovascular disease, and high homocysteine levels are an independent risk factor for liver fibrosis and cirrhosis. Folate deficiency also impairs lipid metabolism in the liver, leading to lipid accumulation and fibrosis. Folate is involved in the methionine cycle, DNA synthesis, and epigenetic regulation, and its deficiency contributes to liver disease progression. Folate deficiency affects liver homeostasis, lipid metabolism, and gene expression, and is associated with increased liver fibrosis and cirrhosis. Folate deficiency is linked to reduced serum folate levels in patients with chronic hepatitis and cirrhosis. Folate deficiency increases the secretion of pro-inflammatory factors and impairs lipid metabolism, leading to liver damage. Folate deficiency is also associated with reduced DNA methylation and altered gene expression in liver diseases. Folate deficiency may promote the development of liver diseases by impairing 1C metabolism and methionine metabolism. Folate deficiency is associated with increased liver fibrosis and cirrhosis, and folate supplementation may help reduce liver damage and improve liver function. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with increased liver fibrosis and cirrhosis, and folate supplementation may help reduce liver damage and improve liver function. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases. Folate deficiency is linked to reduced liver function and increased risk of liver diseases. Folate deficiency is associated with reduced liver function and increased risk of liver diseases.