This review explores the multifaceted role of LIM domain only 7 (LMO7) in cancer, highlighting its significance in tumorigenesis and cancer progression. LMO7, a multifunctional protein with multiple domains, is involved in cell adhesion, cytoskeletal organization, and signaling pathways. Its dysregulation has been implicated in various cancers, including breast, thyroid, lung, pancreatic, and hepatocellular carcinomas. The review discusses the molecular characteristics of LMO7, its interactions with other proteins, and the mechanisms by which it promotes cancer cell proliferation, migration, and invasion. Additionally, it examines the prognostic value of LMO7 expression and the genomic alterations associated with LMO7 in different cancers. Despite its potential as a therapeutic target, challenges in understanding LMO7's complex functions and developing specific inhibitors are noted. The review emphasizes the need for further research to fully understand LMO7's role in cancer and to develop effective targeted therapies.This review explores the multifaceted role of LIM domain only 7 (LMO7) in cancer, highlighting its significance in tumorigenesis and cancer progression. LMO7, a multifunctional protein with multiple domains, is involved in cell adhesion, cytoskeletal organization, and signaling pathways. Its dysregulation has been implicated in various cancers, including breast, thyroid, lung, pancreatic, and hepatocellular carcinomas. The review discusses the molecular characteristics of LMO7, its interactions with other proteins, and the mechanisms by which it promotes cancer cell proliferation, migration, and invasion. Additionally, it examines the prognostic value of LMO7 expression and the genomic alterations associated with LMO7 in different cancers. Despite its potential as a therapeutic target, challenges in understanding LMO7's complex functions and developing specific inhibitors are noted. The review emphasizes the need for further research to fully understand LMO7's role in cancer and to develop effective targeted therapies.