The Role of Endogenous Cannabinoids in Synaptic Signaling, published in Physiological Reviews in 2003, explores the physiological roles of endocannabinoids in the brain. The study highlights the discovery of endogenous compounds with cannabimimetic activity, known as endocannabinoids, and their molecular targets, the CB1 and CB2 receptors. The authors discuss the biosynthetic pathways of endocannabinoids, their release, uptake, and degradation, as well as the distribution of CB1 receptors in the brain. They emphasize the presynaptic localization of CB1 receptors and their role in regulating neurotransmitter release. The study also covers the physiological functions of endocannabinoids, including their involvement in retrograde synaptic signaling and their impact on synaptic plasticity and network activity. The authors conclude that endocannabinoids play a crucial role in modulating brain activity and that further research is needed to fully understand their functions. The study provides a comprehensive overview of the endocannabinoid system and its significance in brain function.The Role of Endogenous Cannabinoids in Synaptic Signaling, published in Physiological Reviews in 2003, explores the physiological roles of endocannabinoids in the brain. The study highlights the discovery of endogenous compounds with cannabimimetic activity, known as endocannabinoids, and their molecular targets, the CB1 and CB2 receptors. The authors discuss the biosynthetic pathways of endocannabinoids, their release, uptake, and degradation, as well as the distribution of CB1 receptors in the brain. They emphasize the presynaptic localization of CB1 receptors and their role in regulating neurotransmitter release. The study also covers the physiological functions of endocannabinoids, including their involvement in retrograde synaptic signaling and their impact on synaptic plasticity and network activity. The authors conclude that endocannabinoids play a crucial role in modulating brain activity and that further research is needed to fully understand their functions. The study provides a comprehensive overview of the endocannabinoid system and its significance in brain function.