The article reviews the role of the skin immune system in wound healing, a complex process involving multiple cell types and stages: hemostasis, inflammation, proliferation, and remodeling. The immune system, both resident and recruited cells, plays a crucial role in monitoring the skin, promoting homeostasis, and facilitating wound repair. Key immune cells include platelets, neutrophils, macrophages, mast cells, T-lymphocytes, and dendritic cells. Platelets initiate hemostasis and release cytokines and chemokines that recruit immune cells. Neutrophils are the first responders, degrading pathogens and releasing antimicrobial substances. Macrophages switch from pro-inflammatory to anti-inflammatory phenotypes, promoting tissue repair. Mast cells release vasoactive and proinflammatory mediators. T-lymphocytes, including Th1, Th2, Th17, Th22, and T-reg cells, contribute to both inflammatory and reparative phases. Dendritic cells present antigens to T cells and participate in the inflammatory response. The article highlights the importance of maintaining a balanced immune response to prevent chronic wounds and other pathological conditions.The article reviews the role of the skin immune system in wound healing, a complex process involving multiple cell types and stages: hemostasis, inflammation, proliferation, and remodeling. The immune system, both resident and recruited cells, plays a crucial role in monitoring the skin, promoting homeostasis, and facilitating wound repair. Key immune cells include platelets, neutrophils, macrophages, mast cells, T-lymphocytes, and dendritic cells. Platelets initiate hemostasis and release cytokines and chemokines that recruit immune cells. Neutrophils are the first responders, degrading pathogens and releasing antimicrobial substances. Macrophages switch from pro-inflammatory to anti-inflammatory phenotypes, promoting tissue repair. Mast cells release vasoactive and proinflammatory mediators. T-lymphocytes, including Th1, Th2, Th17, Th22, and T-reg cells, contribute to both inflammatory and reparative phases. Dendritic cells present antigens to T cells and participate in the inflammatory response. The article highlights the importance of maintaining a balanced immune response to prevent chronic wounds and other pathological conditions.