The skin immune system plays a crucial role in wound healing, which is a complex and dynamic process involving multiple stages: hemostasis, inflammation, proliferation, and remodeling. Immune cells, including resident and recruited cells, contribute to wound repair by releasing cytokines, growth factors, and antimicrobial molecules that promote inflammation, tissue regeneration, and immune responses. During hemostasis, platelets initiate clot formation and release signaling molecules that recruit immune cells. In the inflammatory phase, immune cells such as neutrophils and macrophages eliminate pathogens and debris, while also amplifying the inflammatory response. Macrophages transition from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, supporting tissue repair and remodeling. Mast cells, T cells, and dendritic cells also contribute to immune regulation and wound healing. The balance between immune activation and resolution is essential for proper healing; dysregulation can lead to chronic wounds or pathological conditions. The review highlights the roles of various immune cells in each stage of wound healing, emphasizing the importance of immune system coordination in successful tissue repair.The skin immune system plays a crucial role in wound healing, which is a complex and dynamic process involving multiple stages: hemostasis, inflammation, proliferation, and remodeling. Immune cells, including resident and recruited cells, contribute to wound repair by releasing cytokines, growth factors, and antimicrobial molecules that promote inflammation, tissue regeneration, and immune responses. During hemostasis, platelets initiate clot formation and release signaling molecules that recruit immune cells. In the inflammatory phase, immune cells such as neutrophils and macrophages eliminate pathogens and debris, while also amplifying the inflammatory response. Macrophages transition from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, supporting tissue repair and remodeling. Mast cells, T cells, and dendritic cells also contribute to immune regulation and wound healing. The balance between immune activation and resolution is essential for proper healing; dysregulation can lead to chronic wounds or pathological conditions. The review highlights the roles of various immune cells in each stage of wound healing, emphasizing the importance of immune system coordination in successful tissue repair.