The article reviews the roles of long noncoding RNAs (lncRNAs) in various inflammatory diseases, including cardiovascular disease, osteoarthritis, sepsis, chronic obstructive pulmonary disease, asthma, acute lung injury, diabetic retinopathy, and Parkinson's disease. LncRNAs are emerging as important regulators of gene expression and signaling pathways, playing key roles in the inflammatory response. The authors summarize the expression levels and regulatory mechanisms of lncRNAs in these diseases, focusing on transcription regulation, mRNA stability, miRNA sponge, and signaling pathways. They also discuss the potential applications of lncRNAs as therapeutic targets and biomarkers. Despite the current understanding of lncRNAs being in its infancy, the data provide a theoretical basis for their clinical application in inflammatory diseases. The review highlights the complex regulatory mechanisms of lncRNAs, such as their interaction with DNA, RNA, and proteins, and their involvement in macrophage polarization. The authors conclude by emphasizing the need for further research to fully understand the mechanisms of lncRNAs in inflammatory diseases and to develop therapeutic strategies based on their potential functions.The article reviews the roles of long noncoding RNAs (lncRNAs) in various inflammatory diseases, including cardiovascular disease, osteoarthritis, sepsis, chronic obstructive pulmonary disease, asthma, acute lung injury, diabetic retinopathy, and Parkinson's disease. LncRNAs are emerging as important regulators of gene expression and signaling pathways, playing key roles in the inflammatory response. The authors summarize the expression levels and regulatory mechanisms of lncRNAs in these diseases, focusing on transcription regulation, mRNA stability, miRNA sponge, and signaling pathways. They also discuss the potential applications of lncRNAs as therapeutic targets and biomarkers. Despite the current understanding of lncRNAs being in its infancy, the data provide a theoretical basis for their clinical application in inflammatory diseases. The review highlights the complex regulatory mechanisms of lncRNAs, such as their interaction with DNA, RNA, and proteins, and their involvement in macrophage polarization. The authors conclude by emphasizing the need for further research to fully understand the mechanisms of lncRNAs in inflammatory diseases and to develop therapeutic strategies based on their potential functions.