23 February 2024 | Yunfei Yu, Shengzhuo Liu, Luchen Yang, Pan Song, Zhenghuan Liu, Xiaoyang Liu, Xin Yan, Qiang Dong
Reactive oxygen species (ROS) are a group of oxygen-containing metabolites that play crucial roles in modulating various biological functions. Disruptions in ROS equilibrium are linked to various diseases, and recent insights suggest a dual role for ROS in both tumorigenesis and immune response within cancer. This review comprehensively examines the production and regulatory network of ROS in normal cells, highlighting its impacts on immune cells and its influence on existing immunotherapies. The review also discusses the complex interplay between ROS, inflammation, and tumorigenesis, emphasizing the multifaceted functions of ROS in physiological and pathological conditions. It underscores the potential implications of ROS in cancer immunotherapy and suggests future research directions, including the development of targeted therapies and precision oncology approaches. The review concludes by emphasizing the significance of understanding ROS-mediated mechanisms for advancing cancer therapy and developing personalized treatments.Reactive oxygen species (ROS) are a group of oxygen-containing metabolites that play crucial roles in modulating various biological functions. Disruptions in ROS equilibrium are linked to various diseases, and recent insights suggest a dual role for ROS in both tumorigenesis and immune response within cancer. This review comprehensively examines the production and regulatory network of ROS in normal cells, highlighting its impacts on immune cells and its influence on existing immunotherapies. The review also discusses the complex interplay between ROS, inflammation, and tumorigenesis, emphasizing the multifaceted functions of ROS in physiological and pathological conditions. It underscores the potential implications of ROS in cancer immunotherapy and suggests future research directions, including the development of targeted therapies and precision oncology approaches. The review concludes by emphasizing the significance of understanding ROS-mediated mechanisms for advancing cancer therapy and developing personalized treatments.