2020; 16(10): 1678-1685. doi: 10.7150/ijbs.45053 | Jun Zheng
This review article provides an overview of the emerging coronavirus, SARS-CoV-2, which caused a global outbreak of pneumonia. The authors summarize key events during the early stages of the outbreak, the basic characteristics of the pathogen, signs and symptoms of infected patients, and possible transmission pathways. They highlight bats as the potential natural reservoir and pangolins as possible intermediate hosts, though further investigation is needed. The article also discusses the origin and evolution of SARS-CoV-2, noting its genetic similarity to bat coronaviruses. Additionally, it reviews the current knowledge on chemotherapeutic options for treating SARS-CoV-2 infection, including chloroquine and remdesivir, which have shown promising antiviral activities. The authors emphasize the need for effective preventive measures, vaccine development, and further research into the virus's transmission and evolution.This review article provides an overview of the emerging coronavirus, SARS-CoV-2, which caused a global outbreak of pneumonia. The authors summarize key events during the early stages of the outbreak, the basic characteristics of the pathogen, signs and symptoms of infected patients, and possible transmission pathways. They highlight bats as the potential natural reservoir and pangolins as possible intermediate hosts, though further investigation is needed. The article also discusses the origin and evolution of SARS-CoV-2, noting its genetic similarity to bat coronaviruses. Additionally, it reviews the current knowledge on chemotherapeutic options for treating SARS-CoV-2 infection, including chloroquine and remdesivir, which have shown promising antiviral activities. The authors emphasize the need for effective preventive measures, vaccine development, and further research into the virus's transmission and evolution.