Elsevier established a free COVID-19 resource center in January 2020, offering English and Mandarin information on the virus. The center grants permission for free access to its research in PubMed Central and other repositories. The article reviews the role of cytokines in COVID-19, focusing on their involvement in disease progression and potential therapeutic approaches. SARS-CoV-2 infection triggers a complex immune response, leading to the overproduction of pro-inflammatory cytokines such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, which can cause severe inflammation and organ damage. The study highlights the importance of cytokine regulation in managing the disease, with treatments targeting cytokine storms, such as IL-6 and TNF-α inhibitors. The article also discusses the role of various cytokines, including IL-1, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-17, M-CSF, G-CSF, GM-CSF, IP-10, IFN-γ, MCP-1, and TNF-α, in the pathophysiology of the disease. Elevated levels of these cytokines are associated with severe disease outcomes, and their regulation is crucial for effective treatment strategies. The study emphasizes the need for further research to develop targeted therapies for managing the cytokine storm and improving patient outcomes in severe cases of COVID-19.Elsevier established a free COVID-19 resource center in January 2020, offering English and Mandarin information on the virus. The center grants permission for free access to its research in PubMed Central and other repositories. The article reviews the role of cytokines in COVID-19, focusing on their involvement in disease progression and potential therapeutic approaches. SARS-CoV-2 infection triggers a complex immune response, leading to the overproduction of pro-inflammatory cytokines such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, which can cause severe inflammation and organ damage. The study highlights the importance of cytokine regulation in managing the disease, with treatments targeting cytokine storms, such as IL-6 and TNF-α inhibitors. The article also discusses the role of various cytokines, including IL-1, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-17, M-CSF, G-CSF, GM-CSF, IP-10, IFN-γ, MCP-1, and TNF-α, in the pathophysiology of the disease. Elevated levels of these cytokines are associated with severe disease outcomes, and their regulation is crucial for effective treatment strategies. The study emphasizes the need for further research to develop targeted therapies for managing the cytokine storm and improving patient outcomes in severe cases of COVID-19.