Since January 2020, Elsevier has established a COVID-19 resource center on its public news and information website, Elsevier Connect, providing free information in English and Mandarin about the novel coronavirus. The company has granted permission to make all its COVID-19-related research available in PubMed Central and other publicly funded repositories, allowing unrestricted research reuse and analyses with acknowledgment of the original source. This permission is valid as long as the COVID-19 resource center remains active. The article "SARS-CoV-2 Infection: The Role of Cytokines in COVID-19 Disease" reviews published data on the alterations in cytokine expression in patients with COVID-19 who require admission to an intensive care unit. It highlights the role of cytokines in the progression of the disease and their impact on outcomes, aiming to support the development of more effective management strategies for COVID-19. The study discusses key cytokines such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, and their involvement in the hyperinflammatory response and disease severity. The article also explores potential therapeutic approaches, including the use of monoclonal antibodies and other treatments to reduce cytokine levels and mitigate the cytokine storm.Since January 2020, Elsevier has established a COVID-19 resource center on its public news and information website, Elsevier Connect, providing free information in English and Mandarin about the novel coronavirus. The company has granted permission to make all its COVID-19-related research available in PubMed Central and other publicly funded repositories, allowing unrestricted research reuse and analyses with acknowledgment of the original source. This permission is valid as long as the COVID-19 resource center remains active. The article "SARS-CoV-2 Infection: The Role of Cytokines in COVID-19 Disease" reviews published data on the alterations in cytokine expression in patients with COVID-19 who require admission to an intensive care unit. It highlights the role of cytokines in the progression of the disease and their impact on outcomes, aiming to support the development of more effective management strategies for COVID-19. The study discusses key cytokines such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, and their involvement in the hyperinflammatory response and disease severity. The article also explores potential therapeutic approaches, including the use of monoclonal antibodies and other treatments to reduce cytokine levels and mitigate the cytokine storm.