This chapter discusses the discovery of satellite cells, which are closely associated with skeletal muscle fibers in frogs. These cells were observed during an electron microscopic study of the tibialis anticus muscle and were found to be present in limited numbers. The satellite cells appear as a small, electron-dense structure wedged between the plasma membrane of the muscle fiber and the basement membrane, often protruding inward and pushing aside the myofibrils. The exact origin and function of these cells remain unclear, but they have been suggested to be remnants from embryonic development or "wandering" cells that can be mobilized under certain conditions. The presence of satellite cells has also been observed in other muscles of frogs and rats, indicating their potential role in muscle regeneration. The chapter concludes by highlighting the need for further research to determine the true nature and significance of satellite cells.This chapter discusses the discovery of satellite cells, which are closely associated with skeletal muscle fibers in frogs. These cells were observed during an electron microscopic study of the tibialis anticus muscle and were found to be present in limited numbers. The satellite cells appear as a small, electron-dense structure wedged between the plasma membrane of the muscle fiber and the basement membrane, often protruding inward and pushing aside the myofibrils. The exact origin and function of these cells remain unclear, but they have been suggested to be remnants from embryonic development or "wandering" cells that can be mobilized under certain conditions. The presence of satellite cells has also been observed in other muscles of frogs and rats, indicating their potential role in muscle regeneration. The chapter concludes by highlighting the need for further research to determine the true nature and significance of satellite cells.