SERUM AND URINARY LYSOZYME (MURAMIDASE) IN MONOCYTIC AND MONOMYELOCYTIC LEUKEMIA

SERUM AND URINARY LYSOZYME (MURAMIDASE) IN MONOCYTIC AND MONOMYELOCYTIC LEUKEMIA

1 May 1966 | ELLIOTT F. OSSERMAN, M.D., AND DOLORES P. LAWLR
A study by Elliott F. Osserman and Dolores P. Lawlor found that patients with monocytic and monomyelocytic leukemia excrete large amounts of a cationic protein (CP) with lysozyme-like properties in their urine. This CP-lysozyme was identified as a low molecular weight enzyme that is overproduced in these patients. The study used electrophoresis, immunological, and enzymatic techniques to analyze the CP-lysozyme in serum and urine samples from 10 patients and 250 others with various diseases. The CP-lysozyme was isolated and characterized, and its enzymatic activity was measured using various methods, including the lyso-plate assay. The results showed that CP-lysozyme levels were significantly higher in the urine of monocytic leukemia patients compared to normal subjects. The study also found that CP-lysozyme levels in the serum of these patients were elevated, but not detected by electrophoresis. The CP-lysozyme was identified as the normal enzyme that is overproduced in these patients. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in theA study by Elliott F. Osserman and Dolores P. Lawlor found that patients with monocytic and monomyelocytic leukemia excrete large amounts of a cationic protein (CP) with lysozyme-like properties in their urine. This CP-lysozyme was identified as a low molecular weight enzyme that is overproduced in these patients. The study used electrophoresis, immunological, and enzymatic techniques to analyze the CP-lysozyme in serum and urine samples from 10 patients and 250 others with various diseases. The CP-lysozyme was isolated and characterized, and its enzymatic activity was measured using various methods, including the lyso-plate assay. The results showed that CP-lysozyme levels were significantly higher in the urine of monocytic leukemia patients compared to normal subjects. The study also found that CP-lysozyme levels in the serum of these patients were elevated, but not detected by electrophoresis. The CP-lysozyme was identified as the normal enzyme that is overproduced in these patients. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the urine of patients with monocytic leukemia compared to normal subjects. The study also found that CP-lysozyme levels were significantly higher in the
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