SIRT1, a member of the sirtuin family, is a NAD+-dependent histone deacetylase involved in various cellular processes, including metabolism, stress response, DNA repair, and inflammation. It has been linked to longevity and healthspan extension in multiple organisms, including yeast, worms, flies, and mice. SIRT1 activity is increased by calorie restriction (CR) and by compounds such as resveratrol, a polyphenol found in red wine. Resveratrol activates SIRT1 and mimics the effects of CR, improving health and extending lifespan in various species. However, resveratrol has low bioavailability in humans, limiting its clinical effectiveness. Other SIRT1 activators, such as SRT1720 and SRT2104, have shown promise in extending healthspan and lifespan in mice. SIRT1 also plays a role in aging-related diseases, with both pro- and anti-aging effects depending on context. SIRT1 inhibitors, such as Selisistat, have been used in clinical trials for Huntington's disease. Overall, SIRT1 is a key regulator of aging and health, with potential as a therapeutic target for age-related diseases. Research on SIRT1 and its activators continues to provide insights into the molecular mechanisms of aging and the development of interventions to promote healthy aging.SIRT1, a member of the sirtuin family, is a NAD+-dependent histone deacetylase involved in various cellular processes, including metabolism, stress response, DNA repair, and inflammation. It has been linked to longevity and healthspan extension in multiple organisms, including yeast, worms, flies, and mice. SIRT1 activity is increased by calorie restriction (CR) and by compounds such as resveratrol, a polyphenol found in red wine. Resveratrol activates SIRT1 and mimics the effects of CR, improving health and extending lifespan in various species. However, resveratrol has low bioavailability in humans, limiting its clinical effectiveness. Other SIRT1 activators, such as SRT1720 and SRT2104, have shown promise in extending healthspan and lifespan in mice. SIRT1 also plays a role in aging-related diseases, with both pro- and anti-aging effects depending on context. SIRT1 inhibitors, such as Selisistat, have been used in clinical trials for Huntington's disease. Overall, SIRT1 is a key regulator of aging and health, with potential as a therapeutic target for age-related diseases. Research on SIRT1 and its activators continues to provide insights into the molecular mechanisms of aging and the development of interventions to promote healthy aging.