This review article explores the role of SIRT7, a member of the sirtuin family of NAD+-dependent deacetylases, in cancer. SIRT7 stands out among other sirtuins due to its unique functions and context-dependent roles in tumorigenesis. It is primarily localized in the nucleolus, where it plays a crucial role in maintaining genomic stability and ribosome biogenesis. SIRT7's functions include regulating nucleolar functions, interacting with RNA metabolism and processing, and exhibiting complex multienzymatic activities. The article highlights SIRT7's dual role in both tumor suppression and promotion, depending on the cellular context. It discusses the intricate molecular mechanisms by which SIRT7 influences various cancers, including its effects on cell cycle progression, apoptosis, and immune evasion. Additionally, the review delves into SIRT7's unique catalytic activities, such as deacetylation of specific histone marks and RNA binding, and its potential as a therapeutic target for cancer treatment. The article concludes by emphasizing the potential of SIRT7 as a diagnostic marker, prognostic indicator, and therapeutic target in personalized cancer treatment.This review article explores the role of SIRT7, a member of the sirtuin family of NAD+-dependent deacetylases, in cancer. SIRT7 stands out among other sirtuins due to its unique functions and context-dependent roles in tumorigenesis. It is primarily localized in the nucleolus, where it plays a crucial role in maintaining genomic stability and ribosome biogenesis. SIRT7's functions include regulating nucleolar functions, interacting with RNA metabolism and processing, and exhibiting complex multienzymatic activities. The article highlights SIRT7's dual role in both tumor suppression and promotion, depending on the cellular context. It discusses the intricate molecular mechanisms by which SIRT7 influences various cancers, including its effects on cell cycle progression, apoptosis, and immune evasion. Additionally, the review delves into SIRT7's unique catalytic activities, such as deacetylation of specific histone marks and RNA binding, and its potential as a therapeutic target for cancer treatment. The article concludes by emphasizing the potential of SIRT7 as a diagnostic marker, prognostic indicator, and therapeutic target in personalized cancer treatment.