The article provides an overview of recent updates and new developments in the SMART (Simple Modular Architecture Research Tool) database, a web resource for protein domain identification and annotation. Key highlights include: 1. **Expanded Domain Coverage**: Over 200 new domains have been added, bringing the total to 1204 distinct modules. 2. **Updated Protein Databases**: The database now includes over 33 million proteins from 350,000 species, with a significant expansion in the 'genomic' mode, covering 2031 species. 3. **Redesigned Protein Annotation Pages**: A new vector-based display engine for protein schematics, improved taxonomic tree displays, and enhanced user interaction features. 4. **New External Information Sources**: Post-translational modification data from PTMcode and detailed orthology information from eggNOG. 5. **Expanded Biological Pathway and Protein Interaction Data**: Synchronized with the STRING database, providing graphical representations of interaction partners for over 9.5 million proteins. 6. **Backend Optimizations**: Significant backend restructuring to handle increased domain and protein feature annotations, improving query performance. These updates enhance the functionality and usability of SMART, making it a valuable resource for researchers in protein domain analysis.The article provides an overview of recent updates and new developments in the SMART (Simple Modular Architecture Research Tool) database, a web resource for protein domain identification and annotation. Key highlights include: 1. **Expanded Domain Coverage**: Over 200 new domains have been added, bringing the total to 1204 distinct modules. 2. **Updated Protein Databases**: The database now includes over 33 million proteins from 350,000 species, with a significant expansion in the 'genomic' mode, covering 2031 species. 3. **Redesigned Protein Annotation Pages**: A new vector-based display engine for protein schematics, improved taxonomic tree displays, and enhanced user interaction features. 4. **New External Information Sources**: Post-translational modification data from PTMcode and detailed orthology information from eggNOG. 5. **Expanded Biological Pathway and Protein Interaction Data**: Synchronized with the STRING database, providing graphical representations of interaction partners for over 9.5 million proteins. 6. **Backend Optimizations**: Significant backend restructuring to handle increased domain and protein feature annotations, improving query performance. These updates enhance the functionality and usability of SMART, making it a valuable resource for researchers in protein domain analysis.