The article "SMART 6: recent updates and new developments" by Ivica Letunic, Tobias Doerks, and Peer Bork, published in *Nucleic Acids Research*, discusses the latest enhancements and features of the Simple Modular Architecture Research Tool (SMART). SMART is an online tool for identifying and annotating protein domains, providing a user-friendly platform for exploring and comparing domain architectures in proteins and genes. The current release includes 784 manually curated protein domain models, with 120 new domains added, bringing the total to nearly 800. The protein database has been expanded to include 630 species, up from 191 in the previous release, and the interaction network view now supports over 2 million proteins. Recent developments focus on data integration and user friendliness. The tool now integrates information on metabolic pathways, mapping the genomic protein database to KEGG orthologous groups and their metabolic pathways. This integration is reflected in the protein annotation pages, where a new 'Metabolic pathways' entry lists the pathways where a domain is present. Additionally, the interaction network data has been significantly expanded and updated, with data imported from the STRING database. The database and web server have been optimized for faster response times and better performance. The core of SMART is a relational database management system, and the server has been distributed across a hardware cluster to handle increased load. The user interface has been streamlined, with extended information on detected SMART domains and Pfam domains, as well as 3D structure information. Two new modes of database access are offered: Distributed Annotation System (DAS) and a web service using Simple Object Access Protocol (SOAP). The authors conclude that SMART continues to expand its coverage and implement new features to enhance the user experience, maintaining its goal of providing high-quality, user-friendly biological resources.The article "SMART 6: recent updates and new developments" by Ivica Letunic, Tobias Doerks, and Peer Bork, published in *Nucleic Acids Research*, discusses the latest enhancements and features of the Simple Modular Architecture Research Tool (SMART). SMART is an online tool for identifying and annotating protein domains, providing a user-friendly platform for exploring and comparing domain architectures in proteins and genes. The current release includes 784 manually curated protein domain models, with 120 new domains added, bringing the total to nearly 800. The protein database has been expanded to include 630 species, up from 191 in the previous release, and the interaction network view now supports over 2 million proteins. Recent developments focus on data integration and user friendliness. The tool now integrates information on metabolic pathways, mapping the genomic protein database to KEGG orthologous groups and their metabolic pathways. This integration is reflected in the protein annotation pages, where a new 'Metabolic pathways' entry lists the pathways where a domain is present. Additionally, the interaction network data has been significantly expanded and updated, with data imported from the STRING database. The database and web server have been optimized for faster response times and better performance. The core of SMART is a relational database management system, and the server has been distributed across a hardware cluster to handle increased load. The user interface has been streamlined, with extended information on detected SMART domains and Pfam domains, as well as 3D structure information. Two new modes of database access are offered: Distributed Annotation System (DAS) and a web service using Simple Object Access Protocol (SOAP). The authors conclude that SMART continues to expand its coverage and implement new features to enhance the user experience, maintaining its goal of providing high-quality, user-friendly biological resources.