The SMART 6 tool, developed by EMBL, provides an online platform for identifying and annotating protein domains. It allows users to explore and compare domain architectures in proteins and genes. The current release includes 784 manually curated protein domains. Recent updates focus on data integration and user-friendliness. The protein database has been expanded to include 630 species, compared to 191 in the previous version. New features include integration of biological pathway data, such as metabolic pathways, and links to pathway resources. The interaction network view has been redesigned and is now available for over 2 million proteins. Users can access SMART via a web interface, DAS, or SOAP-based web service. The database uses a relational management system and has been optimized for speed and efficiency. The user interface has been improved, with enhanced information on detected domains and integration of Pfam and Interpro data. Domain annotation pages now include information on metabolic pathways. SMART also offers two new access modes for advanced users: DAS and a web service. These updates aim to improve the usability and functionality of SMART for both existing and new users. The tool continues to expand its domain coverage and enhance its features to provide high-quality data and a simple user interface.The SMART 6 tool, developed by EMBL, provides an online platform for identifying and annotating protein domains. It allows users to explore and compare domain architectures in proteins and genes. The current release includes 784 manually curated protein domains. Recent updates focus on data integration and user-friendliness. The protein database has been expanded to include 630 species, compared to 191 in the previous version. New features include integration of biological pathway data, such as metabolic pathways, and links to pathway resources. The interaction network view has been redesigned and is now available for over 2 million proteins. Users can access SMART via a web interface, DAS, or SOAP-based web service. The database uses a relational management system and has been optimized for speed and efficiency. The user interface has been improved, with enhanced information on detected domains and integration of Pfam and Interpro data. Domain annotation pages now include information on metabolic pathways. SMART also offers two new access modes for advanced users: DAS and a web service. These updates aim to improve the usability and functionality of SMART for both existing and new users. The tool continues to expand its domain coverage and enhance its features to provide high-quality data and a simple user interface.