This study investigates the role of STEAP3 in ovarian cancer (OC) and its potential as a therapeutic target. STEAP3, a gene closely associated with ferroptosis, was found to be highly expressed in OC tissues and was an independent prognostic factor for poor outcomes. Through various experiments, the researchers demonstrated that STEAP3 knockdown reduced the proliferation and migration of OC cells by inducing ferroptosis. Mechanistically, STEAP3 knockdown activated the p53/SLC7A11 signaling pathway, leading to increased ferroptosis. In vivo xenograft experiments further confirmed that STEAP3 knockdown inhibited tumor growth by promoting ferroptosis through the p53 pathway. This study identifies STEAP3 as a novel therapeutic target for OC, providing new insights into its role in ferroptosis and potential clinical applications.This study investigates the role of STEAP3 in ovarian cancer (OC) and its potential as a therapeutic target. STEAP3, a gene closely associated with ferroptosis, was found to be highly expressed in OC tissues and was an independent prognostic factor for poor outcomes. Through various experiments, the researchers demonstrated that STEAP3 knockdown reduced the proliferation and migration of OC cells by inducing ferroptosis. Mechanistically, STEAP3 knockdown activated the p53/SLC7A11 signaling pathway, leading to increased ferroptosis. In vivo xenograft experiments further confirmed that STEAP3 knockdown inhibited tumor growth by promoting ferroptosis through the p53 pathway. This study identifies STEAP3 as a novel therapeutic target for OC, providing new insights into its role in ferroptosis and potential clinical applications.