The article presents an updated version of the Screening Tool of Older People's Prescriptions (STOPP) and Screening Tool to Alert to Right Treatment (START) criteria, which were first published in 2008. The authors, from various institutions in Ireland and the UK, conducted a thorough literature review and expert panel consultation to update the criteria based on new evidence and remove obsolete ones. The expert panel, comprising 19 specialists from 13 European countries, reviewed and validated the proposed changes using the Delphi consensus methodology. The final list includes 114 criteria, representing a 31% increase from the original version. New categories were added, such as antiplatelet/anticoagulant drugs, drugs affecting renal function, and drugs increasing anticholinergic burden. The revised criteria aim to minimize inappropriate prescribing in older people, improve medication appropriateness, and reduce adverse drug events (ADEs). The study highlights the clinical relevance and practical value of STOPP/START criteria, which have been shown to significantly reduce ADRs and improve medication appropriateness in hospitalized older patients.The article presents an updated version of the Screening Tool of Older People's Prescriptions (STOPP) and Screening Tool to Alert to Right Treatment (START) criteria, which were first published in 2008. The authors, from various institutions in Ireland and the UK, conducted a thorough literature review and expert panel consultation to update the criteria based on new evidence and remove obsolete ones. The expert panel, comprising 19 specialists from 13 European countries, reviewed and validated the proposed changes using the Delphi consensus methodology. The final list includes 114 criteria, representing a 31% increase from the original version. New categories were added, such as antiplatelet/anticoagulant drugs, drugs affecting renal function, and drugs increasing anticholinergic burden. The revised criteria aim to minimize inappropriate prescribing in older people, improve medication appropriateness, and reduce adverse drug events (ADEs). The study highlights the clinical relevance and practical value of STOPP/START criteria, which have been shown to significantly reduce ADRs and improve medication appropriateness in hospitalized older patients.