The STOPP/START criteria for potentially inappropriate prescribing in older people (version 2) were developed to improve the appropriateness of medication use in older adults. The criteria were updated based on new evidence and expert input. The original 2008 criteria were reviewed, and new criteria were added while obsolete ones were removed. A panel of 19 experts from 13 European countries evaluated the criteria and proposed additional ones. The revised criteria were validated using the Delphi consensus method, resulting in 114 criteria (80 STOPP and 34 START), a 31% increase from version 1. New categories were introduced, such as antiplatelet/anticoagulant drugs, drugs affecting renal function, and those increasing anticholinergic burden for STOPP, and urogenital system drugs, analgesics, and vaccines for START. The criteria are based on updated literature and expert consensus. The study highlights the importance of minimizing inappropriate prescribing in older people, as it is a significant public health issue. The updated criteria aim to improve medication appropriateness and reduce adverse drug reactions. The validation process involved multiple rounds of expert evaluation and consensus. The criteria are intended to guide healthcare professionals in prescribing medications to older adults, ensuring they are appropriate and safe. The study also acknowledges the need for ongoing updates to the criteria as new evidence emerges. The STOPP/START criteria have been shown to significantly improve medication appropriateness and reduce adverse drug reactions in older patients. The criteria are supported by a comprehensive literature review and expert validation. The study emphasizes the importance of using these criteria to ensure safe and appropriate prescribing for older adults. The criteria are based on evidence-based medicine and are intended to be used in clinical practice to improve patient outcomes. The study also notes that while some criteria may not be as critical as others, they are still important for overall prescribing safety. The criteria are regularly updated to reflect new evidence and ensure their continued relevance. The study concludes that the updated STOPP/START criteria are essential for improving the safety and appropriateness of prescribing in older adults.The STOPP/START criteria for potentially inappropriate prescribing in older people (version 2) were developed to improve the appropriateness of medication use in older adults. The criteria were updated based on new evidence and expert input. The original 2008 criteria were reviewed, and new criteria were added while obsolete ones were removed. A panel of 19 experts from 13 European countries evaluated the criteria and proposed additional ones. The revised criteria were validated using the Delphi consensus method, resulting in 114 criteria (80 STOPP and 34 START), a 31% increase from version 1. New categories were introduced, such as antiplatelet/anticoagulant drugs, drugs affecting renal function, and those increasing anticholinergic burden for STOPP, and urogenital system drugs, analgesics, and vaccines for START. The criteria are based on updated literature and expert consensus. The study highlights the importance of minimizing inappropriate prescribing in older people, as it is a significant public health issue. The updated criteria aim to improve medication appropriateness and reduce adverse drug reactions. The validation process involved multiple rounds of expert evaluation and consensus. The criteria are intended to guide healthcare professionals in prescribing medications to older adults, ensuring they are appropriate and safe. The study also acknowledges the need for ongoing updates to the criteria as new evidence emerges. The STOPP/START criteria have been shown to significantly improve medication appropriateness and reduce adverse drug reactions in older patients. The criteria are supported by a comprehensive literature review and expert validation. The study emphasizes the importance of using these criteria to ensure safe and appropriate prescribing for older adults. The criteria are based on evidence-based medicine and are intended to be used in clinical practice to improve patient outcomes. The study also notes that while some criteria may not be as critical as others, they are still important for overall prescribing safety. The criteria are regularly updated to reflect new evidence and ensure their continued relevance. The study concludes that the updated STOPP/START criteria are essential for improving the safety and appropriateness of prescribing in older adults.