This study investigates the production of persistent elevation of systolic blood pressure in dogs by means of renal ischemia. The researchers used a special clamp to constrict the main renal arteries, varying the degree of constriction to observe its effects on blood pressure. The study found that constriction of both renal arteries consistently led to a significant increase in systolic blood pressure, which persisted for up to 15 months. The elevation of blood pressure was accompanied by changes in renal function, including reduced urea clearance and increased levels of urea, creatinine, and total non-protein nitrogen in the blood. In some animals, the severe constriction of both renal arteries resulted in uremia and death. The study concludes that localized ischemia to the kidneys is sufficient to produce persistently elevated systolic blood pressure, similar to the hypertension associated with nephrosclerosis in humans. The findings suggest that ischemic changes in the kidneys may be a key factor in the development of hypertension.This study investigates the production of persistent elevation of systolic blood pressure in dogs by means of renal ischemia. The researchers used a special clamp to constrict the main renal arteries, varying the degree of constriction to observe its effects on blood pressure. The study found that constriction of both renal arteries consistently led to a significant increase in systolic blood pressure, which persisted for up to 15 months. The elevation of blood pressure was accompanied by changes in renal function, including reduced urea clearance and increased levels of urea, creatinine, and total non-protein nitrogen in the blood. In some animals, the severe constriction of both renal arteries resulted in uremia and death. The study concludes that localized ischemia to the kidneys is sufficient to produce persistently elevated systolic blood pressure, similar to the hypertension associated with nephrosclerosis in humans. The findings suggest that ischemic changes in the kidneys may be a key factor in the development of hypertension.