This paper provides a comprehensive overview of sustainable supply chain practices, focusing on innovative initiatives in both the United States (USA) and Africa. The review highlights key sustainable practices, emphasizing environmental responsibility, ethical sourcing, and corporate social responsibility. In the USA, companies are adopting eco-friendly logistics strategies, using renewable energy in transportation, and integrating advanced technologies like IoT and blockchain for transparency and traceability. In Africa, sustainable practices are influenced by socio-economic factors, resource constraints, and the need for inclusive development. Initiatives include local sourcing, community engagement, and fair trade practices. The paper also discusses challenges such as regulatory frameworks, infrastructure limitations, and capacity building. Despite these challenges, the growing recognition of sustainability as a critical business imperative is driving a paradigm shift in supply chain practices. The review contributes to understanding sustainable supply chain practices by examining innovations in both regions, offering insights that can inform global strategies for building resilient, environmentally conscious, and socially responsible supply chains.This paper provides a comprehensive overview of sustainable supply chain practices, focusing on innovative initiatives in both the United States (USA) and Africa. The review highlights key sustainable practices, emphasizing environmental responsibility, ethical sourcing, and corporate social responsibility. In the USA, companies are adopting eco-friendly logistics strategies, using renewable energy in transportation, and integrating advanced technologies like IoT and blockchain for transparency and traceability. In Africa, sustainable practices are influenced by socio-economic factors, resource constraints, and the need for inclusive development. Initiatives include local sourcing, community engagement, and fair trade practices. The paper also discusses challenges such as regulatory frameworks, infrastructure limitations, and capacity building. Despite these challenges, the growing recognition of sustainability as a critical business imperative is driving a paradigm shift in supply chain practices. The review contributes to understanding sustainable supply chain practices by examining innovations in both regions, offering insights that can inform global strategies for building resilient, environmentally conscious, and socially responsible supply chains.