This paper provides a comprehensive overview of sustainable supply chain practices, focusing on innovative initiatives in the United States (USA) and Africa. As the global community faces environmental challenges and seeks a more sustainable future, the supply chain industry plays a key role in driving positive change. The review explores key sustainable supply chain practices, highlighting the distinct approaches taken by businesses in the USA and Africa. In the USA, sustainable supply chain practices emphasize environmental responsibility, ethical sourcing, and corporate social responsibility. Companies are adopting eco-friendly logistics strategies, such as using renewable energy in transportation and distribution networks. The integration of advanced technologies like IoT and blockchain enhances transparency and traceability, ensuring sustainable practices are maintained from production to delivery. In contrast, Africa's sustainable supply chain practices are influenced by socio-economic factors, resource constraints, and the need for inclusive development. Initiatives in Africa focus on local sourcing, community engagement, and fair trade practices. Innovative approaches include using alternative and locally sourced materials and developing eco-friendly packaging solutions. Collaboration between businesses and local communities is crucial for fostering sustainable practices and creating positive social and environmental impacts. The review also highlights challenges faced by both regions, such as regulatory frameworks, infrastructure limitations, and the need for capacity building. Despite these challenges, the growing recognition of sustainability as a critical business imperative is driving a shift in supply chain practices. This review contributes to understanding sustainable supply chain practices by examining innovations in the USA and Africa. By identifying commonalities and differences, it offers insights that can inform global strategies for building resilient, environmentally conscious, and socially responsible supply chains. Sustainable supply chain practices in the USA include eco-friendly logistics, renewable energy use, responsible sourcing, traceability technologies, and initiatives addressing social and environmental impacts. In Africa, sustainable practices are influenced by socio-economic factors, resource constraints, local sourcing, and fair trade. Tailoring these practices to the African context, addressing economic challenges, involving local communities, and fostering ethical business relationships are essential for overcoming challenges and promoting sustainability. Innovations and technologies in the USA include IoT and blockchain, which enhance supply chain efficiency and security. In Africa, localized innovations focus on sustainability and eco-friendliness, such as using alternative materials and eco-friendly packaging. Challenges in sustainable supply chains include regulatory frameworks, infrastructure limitations, and capacity building. While regulatory requirements can improve sustainability reporting quality, challenges remain, particularly for African businesses. Overcoming infrastructure limitations and investing in capacity building are crucial for addressing the multifaceted challenges in sustainable supply chains. Case studies highlight the importance of sustainable supply chain practices in the USA and Africa, providing insights into innovations and strategies. The future outlook of sustainable supply chain practices in the USA and Africa is dynamic, shaped by ongoing innovations and emerging research. The USA is expected to see advancements in strategic and tactical levels of sustainability, while Africa's focus is on resilience in the face of crises. The integration of sustainability and resilience in supply chains is a key research area. The review recommends a collaborative and adaptive approach toThis paper provides a comprehensive overview of sustainable supply chain practices, focusing on innovative initiatives in the United States (USA) and Africa. As the global community faces environmental challenges and seeks a more sustainable future, the supply chain industry plays a key role in driving positive change. The review explores key sustainable supply chain practices, highlighting the distinct approaches taken by businesses in the USA and Africa. In the USA, sustainable supply chain practices emphasize environmental responsibility, ethical sourcing, and corporate social responsibility. Companies are adopting eco-friendly logistics strategies, such as using renewable energy in transportation and distribution networks. The integration of advanced technologies like IoT and blockchain enhances transparency and traceability, ensuring sustainable practices are maintained from production to delivery. In contrast, Africa's sustainable supply chain practices are influenced by socio-economic factors, resource constraints, and the need for inclusive development. Initiatives in Africa focus on local sourcing, community engagement, and fair trade practices. Innovative approaches include using alternative and locally sourced materials and developing eco-friendly packaging solutions. Collaboration between businesses and local communities is crucial for fostering sustainable practices and creating positive social and environmental impacts. The review also highlights challenges faced by both regions, such as regulatory frameworks, infrastructure limitations, and the need for capacity building. Despite these challenges, the growing recognition of sustainability as a critical business imperative is driving a shift in supply chain practices. This review contributes to understanding sustainable supply chain practices by examining innovations in the USA and Africa. By identifying commonalities and differences, it offers insights that can inform global strategies for building resilient, environmentally conscious, and socially responsible supply chains. Sustainable supply chain practices in the USA include eco-friendly logistics, renewable energy use, responsible sourcing, traceability technologies, and initiatives addressing social and environmental impacts. In Africa, sustainable practices are influenced by socio-economic factors, resource constraints, local sourcing, and fair trade. Tailoring these practices to the African context, addressing economic challenges, involving local communities, and fostering ethical business relationships are essential for overcoming challenges and promoting sustainability. Innovations and technologies in the USA include IoT and blockchain, which enhance supply chain efficiency and security. In Africa, localized innovations focus on sustainability and eco-friendliness, such as using alternative materials and eco-friendly packaging. Challenges in sustainable supply chains include regulatory frameworks, infrastructure limitations, and capacity building. While regulatory requirements can improve sustainability reporting quality, challenges remain, particularly for African businesses. Overcoming infrastructure limitations and investing in capacity building are crucial for addressing the multifaceted challenges in sustainable supply chains. Case studies highlight the importance of sustainable supply chain practices in the USA and Africa, providing insights into innovations and strategies. The future outlook of sustainable supply chain practices in the USA and Africa is dynamic, shaped by ongoing innovations and emerging research. The USA is expected to see advancements in strategic and tactical levels of sustainability, while Africa's focus is on resilience in the face of crises. The integration of sustainability and resilience in supply chains is a key research area. The review recommends a collaborative and adaptive approach to