SWECO25 is a comprehensive, cross-thematic raster database for ecological research in Switzerland, designed to address the challenges of scattered and non-standardized data. The database, available at a 25-meter resolution, integrates 5,265 layers across 10 environmental categories: geologic, topographic, bioclimatic, hydrologic, edaphic, land use and cover, population, transportation, vegetation, and remote sensing. Each layer is standardized to a common grid, ensuring uniform resolution, extent, and geographic coordinate system. The development process involved dataset identification, selection, layer processing, and public upload on Zenodo. The layers were validated through automated procedures, and the standardization procedure had minimal impact on output values. SWECO25 aims to facilitate more effective analyses, informed decision-making, collaboration, and sustainable development across various sectors, including biodiversity conservation, glacier and snowmelt modeling, tourism management, natural hazard mitigation, energy transition planning, and ecosystem services assessment. The database is openly available and regularly updated to support ecological research and applications in Switzerland.SWECO25 is a comprehensive, cross-thematic raster database for ecological research in Switzerland, designed to address the challenges of scattered and non-standardized data. The database, available at a 25-meter resolution, integrates 5,265 layers across 10 environmental categories: geologic, topographic, bioclimatic, hydrologic, edaphic, land use and cover, population, transportation, vegetation, and remote sensing. Each layer is standardized to a common grid, ensuring uniform resolution, extent, and geographic coordinate system. The development process involved dataset identification, selection, layer processing, and public upload on Zenodo. The layers were validated through automated procedures, and the standardization procedure had minimal impact on output values. SWECO25 aims to facilitate more effective analyses, informed decision-making, collaboration, and sustainable development across various sectors, including biodiversity conservation, glacier and snowmelt modeling, tourism management, natural hazard mitigation, energy transition planning, and ecosystem services assessment. The database is openly available and regularly updated to support ecological research and applications in Switzerland.