The Saccharomyces Genome Database (SGD) is a comprehensive resource for the budding yeast *Saccharomyces cerevisiae*, providing high-quality, manually curated information from peer-reviewed literature. SGD integrates experimental results, high-throughput data, and quality-controlled Gene Ontology (GO) annotations to facilitate research in genetics, cell biology, and systems biology. The database offers a rich genome browser, Locus Summary pages, and advanced query tools like YeastMine for comprehensive data analysis. SGD also maintains the S. cerevisiae reference genome sequence and supports the integration of new high-throughput data sets, including expression analysis and chromatin structure information. Additionally, SGD provides tools for literature search and community engagement through social media and quarterly newsletters. The database is supported by funding from the National Human Genome Research Institute and the Gene Ontology Consortium.The Saccharomyces Genome Database (SGD) is a comprehensive resource for the budding yeast *Saccharomyces cerevisiae*, providing high-quality, manually curated information from peer-reviewed literature. SGD integrates experimental results, high-throughput data, and quality-controlled Gene Ontology (GO) annotations to facilitate research in genetics, cell biology, and systems biology. The database offers a rich genome browser, Locus Summary pages, and advanced query tools like YeastMine for comprehensive data analysis. SGD also maintains the S. cerevisiae reference genome sequence and supports the integration of new high-throughput data sets, including expression analysis and chromatin structure information. Additionally, SGD provides tools for literature search and community engagement through social media and quarterly newsletters. The database is supported by funding from the National Human Genome Research Institute and the Gene Ontology Consortium.