The article "Safe nanomaterials: from their use, application, and disposal to regulations" by Jorge Antonio Chávez-Hernández, Aida Jimena Velarde-Salcedo, Gabriela Navarro-Tovar, and Carmen Gonzalez, provides a comprehensive overview of the global applications, disposal, and regulatory frameworks for nanomaterials (NMs). NMs, with their diverse applications in various industries, pose significant environmental and health risks that necessitate careful regulation. The authors highlight the importance of developing accurate legislations, frameworks, and guidelines to standardize the use of NMs. The introduction traces the historical development of nanotechnology, from Richard Feynman's 1959 lecture to the recent Nobel Prize-winning work on quantum dots. It emphasizes the economic impact of nanotechnology, noting the increasing number of patents and investments in the field. The article also discusses the role of organizations like the United Nations, World Health Organization (WHO), and the United Nations Environment Program (UNEP) in promoting environmental safety and sustainable development goals (SDGs) related to NMs. The global applications of NMs are discussed, including their use in healthcare, food, cosmetics, and environmental protection. The article highlights the potential benefits and risks associated with NMs, such as their use in vaccines, food additives, and water treatment systems. It also addresses the challenges of disposing of NMs and the need for proper waste management to prevent environmental pollution and health risks. The international regulatory framework for NMs is explored, focusing on the efforts of the World Health Organization, the United Nations, and various national and international organizations. The article discusses the different types of regulations, including mandatory and voluntary measures, and the importance of harmonization at a global level. It also covers the role of registers, labeling, codes of conduct, risk management systems, guidelines, and standards in managing the risks associated with NMs. Overall, the article underscores the need for robust regulations to ensure the safe and responsible use of nanotechnologies, aligning with the principles of the precautionary approach and the SDGs.The article "Safe nanomaterials: from their use, application, and disposal to regulations" by Jorge Antonio Chávez-Hernández, Aida Jimena Velarde-Salcedo, Gabriela Navarro-Tovar, and Carmen Gonzalez, provides a comprehensive overview of the global applications, disposal, and regulatory frameworks for nanomaterials (NMs). NMs, with their diverse applications in various industries, pose significant environmental and health risks that necessitate careful regulation. The authors highlight the importance of developing accurate legislations, frameworks, and guidelines to standardize the use of NMs. The introduction traces the historical development of nanotechnology, from Richard Feynman's 1959 lecture to the recent Nobel Prize-winning work on quantum dots. It emphasizes the economic impact of nanotechnology, noting the increasing number of patents and investments in the field. The article also discusses the role of organizations like the United Nations, World Health Organization (WHO), and the United Nations Environment Program (UNEP) in promoting environmental safety and sustainable development goals (SDGs) related to NMs. The global applications of NMs are discussed, including their use in healthcare, food, cosmetics, and environmental protection. The article highlights the potential benefits and risks associated with NMs, such as their use in vaccines, food additives, and water treatment systems. It also addresses the challenges of disposing of NMs and the need for proper waste management to prevent environmental pollution and health risks. The international regulatory framework for NMs is explored, focusing on the efforts of the World Health Organization, the United Nations, and various national and international organizations. The article discusses the different types of regulations, including mandatory and voluntary measures, and the importance of harmonization at a global level. It also covers the role of registers, labeling, codes of conduct, risk management systems, guidelines, and standards in managing the risks associated with NMs. Overall, the article underscores the need for robust regulations to ensure the safe and responsible use of nanotechnologies, aligning with the principles of the precautionary approach and the SDGs.