This review discusses the global applications, disposal, and regulatory frameworks for nanomaterials (NMs). Nanomaterials are structures with a wide range of applications in various industries, including medical, pharmaceutical, food, textile, and electronics. As a relatively new technological field, the associated risks of NMs to environmental and human health must be addressed to develop accurate regulations, frameworks, and guidelines for their safe use. The review highlights the current efforts of various countries, including Mexico and Latin American countries, international organizations, and departments to implement regulations on NMs, nanotechnology, and nanoscience. It also includes tools, initiatives, and strategies to develop regulatory frameworks, such as life cycle assessments, risk assessments, technical tools, and biological models to evaluate the effects of NMs on living organisms. The authors emphasize the importance of implementing global regulations to promote nanotechnology research based on a precautionary principle focused on environmental and health protection. Nanotechnology has led to numerous nano-based products available in the market, breakthroughs in technology, and synthesis methods. It has accelerated growth in various areas of science and industry. The history of nanotechnology can be traced back to 1959 when Richard Feynman proposed his famous lecture. Since then, fundamental advances in nanotechnology have taken place, including the development of nanomaterials and their applications. The development of new NM-derived products and applications is associated with an increasing number of requested and approved patents. The United States is the leading country in nanotechnology patenting, followed by South Korea, China, Japan, and Taiwan. Nanotechnology has a significant participation in global markets, with sustained growth and future projections showing its importance. For example, the value of nanotechnology was up to 2 trillion USD in 2015, and other projections assessed 2020 a value in the global economy of up to 3 trillion USD. The economic data was before 2020, and the current monetary yields could be far more today, considering the impact of the SARS-CoV2 global pandemic. The review explores and analyzes the current applications and uses of a series of products based on NMs. It also contextualizes aspects related to the disposal, regulations, legislations, and worldwide advances of these materials in the nano scale within the last years. The review emphasizes the current situation in which countries from different continents face the situation of NM regulation, including countries that have designed initiatives with different degrees to contribute to the good use of nanotechnologies. It also stabilizes the importance of the development of these regulations and how they should be strongly related with the Sustainable Development Goals (SDG). The review discusses the global applications of NMs, including their use in cosmetics, food industry, water treatment systems, and agriculture. NMs are used in cosmetics, food industry, water treatment systems, and agriculture. The review also discusses the international regulatory framework for NMs, including the World HealthThis review discusses the global applications, disposal, and regulatory frameworks for nanomaterials (NMs). Nanomaterials are structures with a wide range of applications in various industries, including medical, pharmaceutical, food, textile, and electronics. As a relatively new technological field, the associated risks of NMs to environmental and human health must be addressed to develop accurate regulations, frameworks, and guidelines for their safe use. The review highlights the current efforts of various countries, including Mexico and Latin American countries, international organizations, and departments to implement regulations on NMs, nanotechnology, and nanoscience. It also includes tools, initiatives, and strategies to develop regulatory frameworks, such as life cycle assessments, risk assessments, technical tools, and biological models to evaluate the effects of NMs on living organisms. The authors emphasize the importance of implementing global regulations to promote nanotechnology research based on a precautionary principle focused on environmental and health protection. Nanotechnology has led to numerous nano-based products available in the market, breakthroughs in technology, and synthesis methods. It has accelerated growth in various areas of science and industry. The history of nanotechnology can be traced back to 1959 when Richard Feynman proposed his famous lecture. Since then, fundamental advances in nanotechnology have taken place, including the development of nanomaterials and their applications. The development of new NM-derived products and applications is associated with an increasing number of requested and approved patents. The United States is the leading country in nanotechnology patenting, followed by South Korea, China, Japan, and Taiwan. Nanotechnology has a significant participation in global markets, with sustained growth and future projections showing its importance. For example, the value of nanotechnology was up to 2 trillion USD in 2015, and other projections assessed 2020 a value in the global economy of up to 3 trillion USD. The economic data was before 2020, and the current monetary yields could be far more today, considering the impact of the SARS-CoV2 global pandemic. The review explores and analyzes the current applications and uses of a series of products based on NMs. It also contextualizes aspects related to the disposal, regulations, legislations, and worldwide advances of these materials in the nano scale within the last years. The review emphasizes the current situation in which countries from different continents face the situation of NM regulation, including countries that have designed initiatives with different degrees to contribute to the good use of nanotechnologies. It also stabilizes the importance of the development of these regulations and how they should be strongly related with the Sustainable Development Goals (SDG). The review discusses the global applications of NMs, including their use in cosmetics, food industry, water treatment systems, and agriculture. NMs are used in cosmetics, food industry, water treatment systems, and agriculture. The review also discusses the international regulatory framework for NMs, including the World Health