Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies

Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies

24 November 2009 | Pasquale Strazzullo, professor of medicine,1 Lanfranco D'Elia, clinical lecturer in medicine,1 Ngianga-Bakwin Kandala, principal research fellow in medical statistics,2 Francesco P Cappuccio, professor of cardiovascular medicine and epidemiology2
This meta-analysis examines the relationship between salt intake and the risk of stroke and cardiovascular disease. The study included 13 prospective cohort studies with a total of 177,025 participants and over 11,000 vascular events. The results show that higher salt intake is associated with a significantly increased risk of stroke (relative risk 1.23, 95% confidence interval 1.06 to 1.43; P=0.007) and cardiovascular disease (1.14, 0.99 to 1.32; P=0.07). The associations were more pronounced with larger differences in sodium intake and longer follow-up periods. The study concludes that high salt intake is a significant risk factor for stroke and cardiovascular disease, supporting the need for population-wide reductions in salt intake to prevent these conditions.This meta-analysis examines the relationship between salt intake and the risk of stroke and cardiovascular disease. The study included 13 prospective cohort studies with a total of 177,025 participants and over 11,000 vascular events. The results show that higher salt intake is associated with a significantly increased risk of stroke (relative risk 1.23, 95% confidence interval 1.06 to 1.43; P=0.007) and cardiovascular disease (1.14, 0.99 to 1.32; P=0.07). The associations were more pronounced with larger differences in sodium intake and longer follow-up periods. The study concludes that high salt intake is a significant risk factor for stroke and cardiovascular disease, supporting the need for population-wide reductions in salt intake to prevent these conditions.
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