This review explores the complex interplay between the gut, brain, and microbiota in regulating satiety. Key hormones such as GLP-1, CCK, and PYY are involved in signaling satiety through the vagus nerve. GLP-1, in particular, plays a crucial role in reducing appetite and promoting weight loss. Recent studies show that GLP-1 receptor agonists like liraglutide can alter gut microbiota composition, which in turn affects satiety, lipid metabolism, and fat distribution. The gut microbiota is also involved in the peripheral and central mechanisms that influence satiety, as well as the reward system that drives food intake. Changes in microbiota composition can impact the release of satiety hormones like CCK and GLP-1, which are regulated by microbial-derived products such as short-chain fatty acids (SCFAs). Additionally, the microbiota influences the central nervous system through neurologic pathways, including the hypothalamus, which controls energy balance and satiety. Neurotransmitters such as GABA, serotonin, and oxytocin also play a role in satiety regulation. The review highlights the importance of the gut microbiota in maintaining satiety homeostasis and suggests that targeting the microbiota could be a promising approach for treating metabolic disorders. The study also discusses the impact of artificial sweeteners and stress on microbiota and satiety. Overall, the review emphasizes the interconnectedness of the gut, brain, and microbiota in regulating satiety and energy homeostasis.This review explores the complex interplay between the gut, brain, and microbiota in regulating satiety. Key hormones such as GLP-1, CCK, and PYY are involved in signaling satiety through the vagus nerve. GLP-1, in particular, plays a crucial role in reducing appetite and promoting weight loss. Recent studies show that GLP-1 receptor agonists like liraglutide can alter gut microbiota composition, which in turn affects satiety, lipid metabolism, and fat distribution. The gut microbiota is also involved in the peripheral and central mechanisms that influence satiety, as well as the reward system that drives food intake. Changes in microbiota composition can impact the release of satiety hormones like CCK and GLP-1, which are regulated by microbial-derived products such as short-chain fatty acids (SCFAs). Additionally, the microbiota influences the central nervous system through neurologic pathways, including the hypothalamus, which controls energy balance and satiety. Neurotransmitters such as GABA, serotonin, and oxytocin also play a role in satiety regulation. The review highlights the importance of the gut microbiota in maintaining satiety homeostasis and suggests that targeting the microbiota could be a promising approach for treating metabolic disorders. The study also discusses the impact of artificial sweeteners and stress on microbiota and satiety. Overall, the review emphasizes the interconnectedness of the gut, brain, and microbiota in regulating satiety and energy homeostasis.