The article introduces the new PSIPRED Protein Analysis Workbench, a web-based framework that integrates various protein analysis methods. The workbench offers a streamlined user interface with enhanced features for exploring results, including SOAP and XML-RPC web server access and HADOOP packages for scalable execution. Key algorithms and software available include BioSerf v2.0 for automated homology modeling, FFPred v2.0 for feature-based function prediction, MEMSAT-SVM for transmembrane topology prediction, and HSPred for identifying hot spot residues in protein-protein interfaces. The workbench also provides detailed results pages and a sequence resubmission tool for further analysis. The article highlights the improvements in the user experience, such as reduced processing time and enhanced visualization tools. Additionally, it demonstrates a use case for analyzing a UniProt sequence, showcasing the predictive capabilities of the workbench in identifying domain structures and functional annotations. The workbench is accessible via the UCL Bioinformatics Group website and supports both web-based and local use, making it suitable for a wide range of computational biology applications.The article introduces the new PSIPRED Protein Analysis Workbench, a web-based framework that integrates various protein analysis methods. The workbench offers a streamlined user interface with enhanced features for exploring results, including SOAP and XML-RPC web server access and HADOOP packages for scalable execution. Key algorithms and software available include BioSerf v2.0 for automated homology modeling, FFPred v2.0 for feature-based function prediction, MEMSAT-SVM for transmembrane topology prediction, and HSPred for identifying hot spot residues in protein-protein interfaces. The workbench also provides detailed results pages and a sequence resubmission tool for further analysis. The article highlights the improvements in the user experience, such as reduced processing time and enhanced visualization tools. Additionally, it demonstrates a use case for analyzing a UniProt sequence, showcasing the predictive capabilities of the workbench in identifying domain structures and functional annotations. The workbench is accessible via the UCL Bioinformatics Group website and supports both web-based and local use, making it suitable for a wide range of computational biology applications.