Schizophrenia and other psychoses are associated with an increased risk of violence and violent offending, particularly homicide. However, most of this excess risk is mediated by comorbid substance abuse. The risk in individuals with comorbid substance abuse is similar to that in individuals with substance abuse without psychosis. Public health strategies for violence reduction should focus on the primary and secondary prevention of substance abuse. A systematic review and meta-analysis of 20 studies involving 18,423 individuals with schizophrenia and other psychoses found that the risk of violence was higher in men (OR 4.0) and women (OR 7.9) compared to the general population. The risk was significantly higher in individuals with comorbid substance abuse (OR 8.9) compared to those without (OR 2.1). The risk of homicide was also higher in individuals with psychosis (OR 19.5) compared to the general population. The study found that the risk of violence was not significantly different based on the study's location, outcome measure, or study period. However, the risk was higher in men compared to women. The risk of violence was not significantly different between studies that included both genders and those that included only men or women. The risk of violence was also not significantly different between studies that used register-based data and those that used self-report or informant-based data. The study found that the risk of violence was not significantly different between individuals with schizophrenia and those with other psychoses. The risk of violence was also not significantly different between individuals with substance abuse and those without. However, the risk of violence was higher in individuals with comorbid substance abuse compared to those without. The study found that the risk of violence was not significantly different between individuals with schizophrenia and those with other psychoses. The risk of violence was also not significantly different between individuals with substance abuse and those without. However, the risk of violence was higher in individuals with comorbid substance abuse compared to those without. The study concluded that the increased risk of violence in schizophrenia and other psychoses is largely due to comorbid substance abuse. Public health strategies for violence reduction should focus on the prevention and treatment of substance abuse.Schizophrenia and other psychoses are associated with an increased risk of violence and violent offending, particularly homicide. However, most of this excess risk is mediated by comorbid substance abuse. The risk in individuals with comorbid substance abuse is similar to that in individuals with substance abuse without psychosis. Public health strategies for violence reduction should focus on the primary and secondary prevention of substance abuse. A systematic review and meta-analysis of 20 studies involving 18,423 individuals with schizophrenia and other psychoses found that the risk of violence was higher in men (OR 4.0) and women (OR 7.9) compared to the general population. The risk was significantly higher in individuals with comorbid substance abuse (OR 8.9) compared to those without (OR 2.1). The risk of homicide was also higher in individuals with psychosis (OR 19.5) compared to the general population. The study found that the risk of violence was not significantly different based on the study's location, outcome measure, or study period. However, the risk was higher in men compared to women. The risk of violence was not significantly different between studies that included both genders and those that included only men or women. The risk of violence was also not significantly different between studies that used register-based data and those that used self-report or informant-based data. The study found that the risk of violence was not significantly different between individuals with schizophrenia and those with other psychoses. The risk of violence was also not significantly different between individuals with substance abuse and those without. However, the risk of violence was higher in individuals with comorbid substance abuse compared to those without. The study found that the risk of violence was not significantly different between individuals with schizophrenia and those with other psychoses. The risk of violence was also not significantly different between individuals with substance abuse and those without. However, the risk of violence was higher in individuals with comorbid substance abuse compared to those without. The study concluded that the increased risk of violence in schizophrenia and other psychoses is largely due to comorbid substance abuse. Public health strategies for violence reduction should focus on the prevention and treatment of substance abuse.