This study presents a theoretical investigation of second-order topological insulators (SOTIs) in 2D CrSBr, including monolayer (ML) and bilayer (BL) forms. The ML CrSBr exhibits a ferromagnetic (FM) ground state and features quantized fractional corner charge in its spin-up channel, resulting in fully spin-polarized corner states. The BL CrSBr, on the other hand, adopts an antiferromagnetic (AFM) ground state while retaining SOTI properties, with quantized corner charge in both spin channels. The SOTI properties in both ML and BL structures remain robust against spin-orbital coupling (SOC) and symmetry-breaking perturbations. The work identifies CrSBr as a promising candidate for realizing 2D magnetic SOTIs, encompassing both FM and AFM phases. The study also demonstrates that the corner states in ML CrSBr appear exclusively in the spin-up channel, while those in BL CrSBr exist in both spin channels. These corner states are robust against SOC and symmetry-breaking perturbations, enhancing the feasibility of experimental detection. The findings contribute to the growing family of 2D magnetic SOTIs, offering a platform to explore the interplay between high-order topological phases and magnetism.This study presents a theoretical investigation of second-order topological insulators (SOTIs) in 2D CrSBr, including monolayer (ML) and bilayer (BL) forms. The ML CrSBr exhibits a ferromagnetic (FM) ground state and features quantized fractional corner charge in its spin-up channel, resulting in fully spin-polarized corner states. The BL CrSBr, on the other hand, adopts an antiferromagnetic (AFM) ground state while retaining SOTI properties, with quantized corner charge in both spin channels. The SOTI properties in both ML and BL structures remain robust against spin-orbital coupling (SOC) and symmetry-breaking perturbations. The work identifies CrSBr as a promising candidate for realizing 2D magnetic SOTIs, encompassing both FM and AFM phases. The study also demonstrates that the corner states in ML CrSBr appear exclusively in the spin-up channel, while those in BL CrSBr exist in both spin channels. These corner states are robust against SOC and symmetry-breaking perturbations, enhancing the feasibility of experimental detection. The findings contribute to the growing family of 2D magnetic SOTIs, offering a platform to explore the interplay between high-order topological phases and magnetism.