Secreted aspartic proteases (Saps) are key factors in Candida infections and host-pathogen interactions. These enzymes, produced by various Candida species, play critical roles in biofilm formation, tissue invasion, immune evasion, and antifungal resistance. Saps contribute to the degradation of host proteins, extracellular matrix components, and coagulation cascade proteins, facilitating fungal survival and pathogenesis. They also modulate immune responses by impairing neutrophil and monocyte/macrophage functions, and their activity is linked to the development of antifungal resistance. Saps are potential biomarkers for diagnosing Candida infections and may serve as targets for novel antifungal therapies or vaccine components. The review highlights the complex biology of Saps and their central role in Candida pathogenicity, emphasizing the need for a multidisciplinary approach to develop innovative diagnostic strategies and clinical interventions against candidiasis. Saps are involved in various pathophysiological functions, including biofilm formation, tissue invasion, immune evasion, and antifungal resistance. They contribute to the degradation of host barriers, proteolysis of coagulation cascade components, and modulation of immune responses. Saps also play a role in the degradation of complement proteins, antimicrobial peptides, and antibodies, aiding in immune evasion. The production of Saps is associated with drug resistance in Candida species, and their expression is influenced by environmental factors and antifungal treatments. Understanding the roles of Saps in Candida infections is crucial for developing effective therapeutic strategies.Secreted aspartic proteases (Saps) are key factors in Candida infections and host-pathogen interactions. These enzymes, produced by various Candida species, play critical roles in biofilm formation, tissue invasion, immune evasion, and antifungal resistance. Saps contribute to the degradation of host proteins, extracellular matrix components, and coagulation cascade proteins, facilitating fungal survival and pathogenesis. They also modulate immune responses by impairing neutrophil and monocyte/macrophage functions, and their activity is linked to the development of antifungal resistance. Saps are potential biomarkers for diagnosing Candida infections and may serve as targets for novel antifungal therapies or vaccine components. The review highlights the complex biology of Saps and their central role in Candida pathogenicity, emphasizing the need for a multidisciplinary approach to develop innovative diagnostic strategies and clinical interventions against candidiasis. Saps are involved in various pathophysiological functions, including biofilm formation, tissue invasion, immune evasion, and antifungal resistance. They contribute to the degradation of host barriers, proteolysis of coagulation cascade components, and modulation of immune responses. Saps also play a role in the degradation of complement proteins, antimicrobial peptides, and antibodies, aiding in immune evasion. The production of Saps is associated with drug resistance in Candida species, and their expression is influenced by environmental factors and antifungal treatments. Understanding the roles of Saps in Candida infections is crucial for developing effective therapeutic strategies.