Secreted Aspartic Proteinases (Saps) are crucial in the virulence of *Candida* species, contributing to nutrient extraction, host defense degradation, and internal balance disruption. This review explores the multifaceted roles of Saps, including their importance in biofilm formation, tissue invasion, immune modulation, and antifungal resistance. Saps play a key role in biofilm formation by modifying host or fungal cell surfaces, enhancing adhesion, and promoting cell-to-cell aggregation. They degrade host barriers, such as mucins and epithelial junctions, and extracellular matrix proteins, facilitating fungal spread. Saps also modulate the host immune response by interacting with neutrophils and monocytes/macrophages, influencing cytokine production and complement system activity. Additionally, they contribute to antifungal resistance by degrading host defense proteins and promoting drug resistance. The diagnostic potential of Saps as biomarkers and their use in developing vaccines and protease inhibitors as adjunctive therapies are discussed. Given their central role in *Candida* pathogenicity, a multidisciplinary approach is necessary to advance innovative diagnostic strategies and clinical interventions against candidiasis.Secreted Aspartic Proteinases (Saps) are crucial in the virulence of *Candida* species, contributing to nutrient extraction, host defense degradation, and internal balance disruption. This review explores the multifaceted roles of Saps, including their importance in biofilm formation, tissue invasion, immune modulation, and antifungal resistance. Saps play a key role in biofilm formation by modifying host or fungal cell surfaces, enhancing adhesion, and promoting cell-to-cell aggregation. They degrade host barriers, such as mucins and epithelial junctions, and extracellular matrix proteins, facilitating fungal spread. Saps also modulate the host immune response by interacting with neutrophils and monocytes/macrophages, influencing cytokine production and complement system activity. Additionally, they contribute to antifungal resistance by degrading host defense proteins and promoting drug resistance. The diagnostic potential of Saps as biomarkers and their use in developing vaccines and protease inhibitors as adjunctive therapies are discussed. Given their central role in *Candida* pathogenicity, a multidisciplinary approach is necessary to advance innovative diagnostic strategies and clinical interventions against candidiasis.