Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?

Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?

28 August-4 September 1982 | Davies J, Niall JF, Ryan GB
A study on the mortality of asbestos workers and the effects of asbestos exposure on health is presented. The study includes references to various research papers and reports on the incidence of lung cancer, mesothelioma, and other diseases in asbestos workers. The study also discusses the dose-response relationships for asbestos-related diseases and the implications for hygiene standards. Additionally, the study includes a report on segmental necrotising glomerulonephritis with antineutrophil antibody, which is associated with possible arbovirus aetiology. The report describes eight patients with this condition, who had a generalised illness associated with segmental necrotising glomerulonephritis. The clinical findings and geographic distribution of the cases suggest that infection by a group A arbovirus may have been an aetiological factor. The patients were treated with prednisolone and either cyclophosphamide or azathioprine. Three required haemodialysis, and two also received plasmapheresis. After follow-up for one to five years, all patients were alive and well. The glomerular lesions in these cases were morphologically indistinguishable from those in microscopic polyarteritis nodosa. The staining of neutrophil cytoplasm by these patients' sera was a characteristic diagnostic finding. The study suggests that this condition may be related to epidemic polyarthritis, which is common in this area and caused by Ross River virus. Further serological investigation using IgM antibody as an index of recent infection is needed to establish a causal role for Ross River virus in this form of glomerulonephritis. The study was accepted for publication on 28 June 1982.A study on the mortality of asbestos workers and the effects of asbestos exposure on health is presented. The study includes references to various research papers and reports on the incidence of lung cancer, mesothelioma, and other diseases in asbestos workers. The study also discusses the dose-response relationships for asbestos-related diseases and the implications for hygiene standards. Additionally, the study includes a report on segmental necrotising glomerulonephritis with antineutrophil antibody, which is associated with possible arbovirus aetiology. The report describes eight patients with this condition, who had a generalised illness associated with segmental necrotising glomerulonephritis. The clinical findings and geographic distribution of the cases suggest that infection by a group A arbovirus may have been an aetiological factor. The patients were treated with prednisolone and either cyclophosphamide or azathioprine. Three required haemodialysis, and two also received plasmapheresis. After follow-up for one to five years, all patients were alive and well. The glomerular lesions in these cases were morphologically indistinguishable from those in microscopic polyarteritis nodosa. The staining of neutrophil cytoplasm by these patients' sera was a characteristic diagnostic finding. The study suggests that this condition may be related to epidemic polyarthritis, which is common in this area and caused by Ross River virus. Further serological investigation using IgM antibody as an index of recent infection is needed to establish a causal role for Ross River virus in this form of glomerulonephritis. The study was accepted for publication on 28 June 1982.
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