This article reviews the concept of self-management (SM) interventions for cancer patients and their families, emphasizing the importance of enabling and empowering patients to manage their care across the cancer care continuum. The authors highlight the shift from traditional oncology practices, which often focus on treatment after diagnosis, to a more comprehensive approach that involves patients and families in the management of their care from prevention to end-of-life. They discuss the challenges and benefits of SM, including improved symptom management, quality of life, and patient empowerment. The Chronic Care Model (CCM) is presented as a framework for oncology practices to support SM interventions, emphasizing the need for productive interactions between patients and providers, and the development of mutually determined care plans. The article also reviews several randomized controlled trials demonstrating the effectiveness of SM interventions in various phases of cancer care, from treatment to survivorship and end-of-life care. Finally, the authors emphasize the importance of a common language and set of actions for SM in cancer care and suggest that oncology practices can play a crucial role in enabling patients to manage their own care effectively.This article reviews the concept of self-management (SM) interventions for cancer patients and their families, emphasizing the importance of enabling and empowering patients to manage their care across the cancer care continuum. The authors highlight the shift from traditional oncology practices, which often focus on treatment after diagnosis, to a more comprehensive approach that involves patients and families in the management of their care from prevention to end-of-life. They discuss the challenges and benefits of SM, including improved symptom management, quality of life, and patient empowerment. The Chronic Care Model (CCM) is presented as a framework for oncology practices to support SM interventions, emphasizing the need for productive interactions between patients and providers, and the development of mutually determined care plans. The article also reviews several randomized controlled trials demonstrating the effectiveness of SM interventions in various phases of cancer care, from treatment to survivorship and end-of-life care. Finally, the authors emphasize the importance of a common language and set of actions for SM in cancer care and suggest that oncology practices can play a crucial role in enabling patients to manage their own care effectively.