The article explores the impact of self-stigma and the "why try" effect on life goals and evidence-based practices for individuals with mental illnesses. Self-stigma, characterized by awareness, agreement, and application of stereotypes, leads to reduced self-esteem and self-efficacy, which in turn discourages pursuit of life goals and participation in evidence-based practices. The "why try" effect encompasses these processes and their consequences. Empowerment, a positive countermeasure, enhances self-esteem and self-efficacy, promoting goal attainment and service utilization. Consumer-operated services, group identity, and coming out are strategies to challenge self-stigma and foster empowerment. The article emphasizes the importance of empowering individuals to pursue their goals and participate in evidence-based practices, rather than focusing solely on removing stigma.The article explores the impact of self-stigma and the "why try" effect on life goals and evidence-based practices for individuals with mental illnesses. Self-stigma, characterized by awareness, agreement, and application of stereotypes, leads to reduced self-esteem and self-efficacy, which in turn discourages pursuit of life goals and participation in evidence-based practices. The "why try" effect encompasses these processes and their consequences. Empowerment, a positive countermeasure, enhances self-esteem and self-efficacy, promoting goal attainment and service utilization. Consumer-operated services, group identity, and coming out are strategies to challenge self-stigma and foster empowerment. The article emphasizes the importance of empowering individuals to pursue their goals and participate in evidence-based practices, rather than focusing solely on removing stigma.