The article discusses the self-organization of matter and the evolution of biological macromolecules, focusing on the role of information and selection in the emergence of life. It begins by addressing the question of "cause and effect" in the origin of life, noting that current physics lacks an obvious explanation for life's existence. The text then explores the concept of self-organization, emphasizing that it often involves complex, multi-molecular systems, such as living cells. It also discusses the "chicken-and-egg" problem of whether proteins or nucleic acids came first, suggesting that the question may be better framed in terms of function and information. The article presents a phenomenological theory of selection, which involves the concept of information, selection strains, and equilibrium. It also introduces a stochastic approach to selection, highlighting the limitations of deterministic theories and the role of fluctuations around equilibrium states. The text then focuses on self-organization based on complementary recognition, particularly in nucleic acids, discussing how DNA and RNA interact through complementary base pairing. The article provides a detailed overview of the interplay between nucleic acids and proteins in the reproduction cycle, including the roles of DNA and DNA polymerase, mRNA and RNA polymerase, t-RNA and amino acyl synthetases, ribosomal RNA and proteins, and the operon system. It highlights the complex regulatory mechanisms involved in gene expression, such as the lac operon, and the interactions between repressors and inducers. The text concludes by emphasizing the importance of these molecular interactions in the functioning of living cells and the need for further research in molecular biology.The article discusses the self-organization of matter and the evolution of biological macromolecules, focusing on the role of information and selection in the emergence of life. It begins by addressing the question of "cause and effect" in the origin of life, noting that current physics lacks an obvious explanation for life's existence. The text then explores the concept of self-organization, emphasizing that it often involves complex, multi-molecular systems, such as living cells. It also discusses the "chicken-and-egg" problem of whether proteins or nucleic acids came first, suggesting that the question may be better framed in terms of function and information. The article presents a phenomenological theory of selection, which involves the concept of information, selection strains, and equilibrium. It also introduces a stochastic approach to selection, highlighting the limitations of deterministic theories and the role of fluctuations around equilibrium states. The text then focuses on self-organization based on complementary recognition, particularly in nucleic acids, discussing how DNA and RNA interact through complementary base pairing. The article provides a detailed overview of the interplay between nucleic acids and proteins in the reproduction cycle, including the roles of DNA and DNA polymerase, mRNA and RNA polymerase, t-RNA and amino acyl synthetases, ribosomal RNA and proteins, and the operon system. It highlights the complex regulatory mechanisms involved in gene expression, such as the lac operon, and the interactions between repressors and inducers. The text concludes by emphasizing the importance of these molecular interactions in the functioning of living cells and the need for further research in molecular biology.