The article "Senescence and Aging: Causes, Consequences, and Therapeutic Avenues" by Domhnall McHugh and Jesús Gil reviews the role of cellular senescence in aging and age-related diseases. Senescence is a cellular response characterized by stable growth arrest and phenotypic alterations, including a proinflammatory secretome. It plays roles in normal development, tissue homeostasis, and tumor suppression but also contributes to age-related diseases such as cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The accumulation of senescent cells with age is a major driver of age-related dysfunction. The article discusses the molecular and cellular links between senescence and aging, highlighting the importance of pathways like p53 and the INK4/ARF locus in regulating senescence. It also explores the senescence-associated secretory phenotype (SASP), which contributes to chronic inflammation and tissue dysfunction. Recent studies using senolytic drugs and genetic models have shown that targeting senescent cells can improve health span and delay age-related diseases. The article concludes by discussing potential therapeutic avenues, including the use of senolytics and SASP-modulating drugs, to address the detrimental effects of senescence during aging.The article "Senescence and Aging: Causes, Consequences, and Therapeutic Avenues" by Domhnall McHugh and Jesús Gil reviews the role of cellular senescence in aging and age-related diseases. Senescence is a cellular response characterized by stable growth arrest and phenotypic alterations, including a proinflammatory secretome. It plays roles in normal development, tissue homeostasis, and tumor suppression but also contributes to age-related diseases such as cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The accumulation of senescent cells with age is a major driver of age-related dysfunction. The article discusses the molecular and cellular links between senescence and aging, highlighting the importance of pathways like p53 and the INK4/ARF locus in regulating senescence. It also explores the senescence-associated secretory phenotype (SASP), which contributes to chronic inflammation and tissue dysfunction. Recent studies using senolytic drugs and genetic models have shown that targeting senescent cells can improve health span and delay age-related diseases. The article concludes by discussing potential therapeutic avenues, including the use of senolytics and SASP-modulating drugs, to address the detrimental effects of senescence during aging.