This study aims to develop an Android-based application called SERLI to support natural science learning for students. The application was developed using the Hannafin & Peck model, which includes needs analysis, design stages, and implementation & development. The evaluation of user satisfaction used the End User Computing Satisfaction (EUCS) method, considering variables such as content, accuracy, display format, ease of use, and timeliness. Experts tested the application and achieved a 86.58% success rate, while students and teachers also evaluated the application and achieved an 85% success rate. The application contains a science lesson module and includes an initial display for registration, a main display with modules and practice questions, and a display for teachers. The application is designed to be engaging and interactive, featuring images, music, and colorful content. The application was tested using blackbox testing to ensure its functionality aligns with user expectations. The results indicate that the application is suitable for use as an Android-based natural science learning module for students. The application provides accessibility and mobility, allowing students and teachers to access it anytime and anywhere. The study concludes that the application is effective in supporting natural science learning and is recommended for further development with more diverse content and video support.This study aims to develop an Android-based application called SERLI to support natural science learning for students. The application was developed using the Hannafin & Peck model, which includes needs analysis, design stages, and implementation & development. The evaluation of user satisfaction used the End User Computing Satisfaction (EUCS) method, considering variables such as content, accuracy, display format, ease of use, and timeliness. Experts tested the application and achieved a 86.58% success rate, while students and teachers also evaluated the application and achieved an 85% success rate. The application contains a science lesson module and includes an initial display for registration, a main display with modules and practice questions, and a display for teachers. The application is designed to be engaging and interactive, featuring images, music, and colorful content. The application was tested using blackbox testing to ensure its functionality aligns with user expectations. The results indicate that the application is suitable for use as an Android-based natural science learning module for students. The application provides accessibility and mobility, allowing students and teachers to access it anytime and anywhere. The study concludes that the application is effective in supporting natural science learning and is recommended for further development with more diverse content and video support.