Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study

June 11, 2020 | Silvia Stringhini, Ania Wisniak, Giovanni Piumatti, Andrew S Azman, Stephen A Lauer, Hélène Baysson, David De Ridder, Dusan Petrovic, Stephanie Schrempt, Kailing Marcus, Sabine Yerly, Isabelle Arm Vernez, Olivia Keiser, Samia Hurst, Klara M Posfay-Barbe, Didier Trono, Didier Pittet, Laurent Gétaz, François Chappuis, Isabella Eckerle, Nicolas Vuilleumier, Benjamin Meyer, Antoine Flahault, Laurent Kaiser, Idris Guessous
Elsevier created a COVID-19 resource centre in 2020 to provide free information on the virus in English and Mandarin. The centre is hosted on Elsevier Connect, offering access to research for unrestricted reuse. A study titled "Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study" assessed the spread of the virus through antibody testing. The study involved 2766 participants from 1339 households in Geneva, estimating weekly seroprevalence of anti-SARS-CoV-2 IgG antibodies. Results showed seroprevalence increasing from 4.8% in the first week to 10.8% in the fifth week. Young children aged 5–9 years and those over 65 had significantly lower seropositivity. The study estimated that for every confirmed case, there were 11.6 community infections. These findings suggest that most of Geneva's population remained uninfected during the pandemic wave, despite high reported cases. The study highlights the need for continued public health measures as immunity levels are not yet sufficient to end the epidemic. The research was funded by various Swiss health organizations and institutions. The study used a Bayesian logistic regression model to estimate seroprevalence, accounting for test performance and demographic factors. The results provide insights into transmission patterns and the immunological state of the population, informing public health strategies globally.Elsevier created a COVID-19 resource centre in 2020 to provide free information on the virus in English and Mandarin. The centre is hosted on Elsevier Connect, offering access to research for unrestricted reuse. A study titled "Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study" assessed the spread of the virus through antibody testing. The study involved 2766 participants from 1339 households in Geneva, estimating weekly seroprevalence of anti-SARS-CoV-2 IgG antibodies. Results showed seroprevalence increasing from 4.8% in the first week to 10.8% in the fifth week. Young children aged 5–9 years and those over 65 had significantly lower seropositivity. The study estimated that for every confirmed case, there were 11.6 community infections. These findings suggest that most of Geneva's population remained uninfected during the pandemic wave, despite high reported cases. The study highlights the need for continued public health measures as immunity levels are not yet sufficient to end the epidemic. The research was funded by various Swiss health organizations and institutions. The study used a Bayesian logistic regression model to estimate seroprevalence, accounting for test performance and demographic factors. The results provide insights into transmission patterns and the immunological state of the population, informing public health strategies globally.
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