The study by Gilad et al. (2008) explores the potential of serum microRNAs as novel biomarkers for clinical diagnosis. MicroRNAs, small non-coding RNAs involved in various biological and pathological processes, were found to be present in bodily fluids, including serum and urine. The researchers developed a qRT-PCR platform to extract and quantify microRNAs, demonstrating that microRNA levels in serum are stable and can reflect physiological conditions. Specifically, they observed that microRNAs associated with the human placenta were significantly elevated in the sera of pregnant women, with their levels correlating with pregnancy stage. This finding highlights the potential of microRNAs as useful clinical biomarkers, particularly for conditions like pregnancy complications and cancer, where microRNAs play a critical role. The study also emphasizes the practicality and reliability of determining microRNA profiles in body fluids, paving the way for their broader application in both research and clinical settings.The study by Gilad et al. (2008) explores the potential of serum microRNAs as novel biomarkers for clinical diagnosis. MicroRNAs, small non-coding RNAs involved in various biological and pathological processes, were found to be present in bodily fluids, including serum and urine. The researchers developed a qRT-PCR platform to extract and quantify microRNAs, demonstrating that microRNA levels in serum are stable and can reflect physiological conditions. Specifically, they observed that microRNAs associated with the human placenta were significantly elevated in the sera of pregnant women, with their levels correlating with pregnancy stage. This finding highlights the potential of microRNAs as useful clinical biomarkers, particularly for conditions like pregnancy complications and cancer, where microRNAs play a critical role. The study also emphasizes the practicality and reliability of determining microRNA profiles in body fluids, paving the way for their broader application in both research and clinical settings.