The study by Vaccarino et al. investigates sex-based differences in early mortality after myocardial infarction (MI) among patients aged 30 to 89 years, as recorded in the National Registry of Myocardial Infarction 2. The overall mortality rate during hospitalization was 16.7% for women and 11.5% for men. The sex-based differences in mortality varied with age, with younger women (younger than 50 years) having more than twice the mortality rate compared to younger men. This difference decreased with increasing age and became non-significant after 74 years. Logistic regression analysis showed that the odds of death were 11.1% greater for women than for men for every five-year decrease in age, and this difference persisted even after adjusting for medical history, clinical severity, and early management. The study concludes that younger women, but not older women, have higher rates of death during hospitalization after MI compared to men of the same age, highlighting the need for special attention to this high-risk group.The study by Vaccarino et al. investigates sex-based differences in early mortality after myocardial infarction (MI) among patients aged 30 to 89 years, as recorded in the National Registry of Myocardial Infarction 2. The overall mortality rate during hospitalization was 16.7% for women and 11.5% for men. The sex-based differences in mortality varied with age, with younger women (younger than 50 years) having more than twice the mortality rate compared to younger men. This difference decreased with increasing age and became non-significant after 74 years. Logistic regression analysis showed that the odds of death were 11.1% greater for women than for men for every five-year decrease in age, and this difference persisted even after adjusting for medical history, clinical severity, and early management. The study concludes that younger women, but not older women, have higher rates of death during hospitalization after MI compared to men of the same age, highlighting the need for special attention to this high-risk group.