The 2015 CDC Sexually Transmitted Diseases (STD) Treatment Guidelines update the 2010 guidelines to address new evidence and clinical practices. These guidelines aim to assist healthcare providers in the prevention and treatment of STDs. They cover alternative treatment regimens for gonorrhea, nucleic acid amplification tests for trichomoniasis, alternative treatments for genital warts, the role of Mycoplasma genitalium in urethritis, updated HPV vaccine recommendations, management of transgender individuals, annual hepatitis C testing for HIV-positive persons, updated diagnostic evaluation for urethritis, and retesting for repeat infections. The guidelines emphasize treatment but also include prevention strategies and diagnostic recommendations. The guidelines were developed by CDC staff and an independent workgroup of experts in STD management. They reviewed the latest literature, focusing on four outcomes of STD therapy: microbiologic eradication, symptom relief, prevention of complications, and transmission prevention. The workgroup evaluated the quality of evidence and rated recommendations using the USPSTF system. The guidelines are applicable in various healthcare settings and are intended for use by healthcare providers to guide clinical decisions. The guidelines emphasize the importance of accurate risk assessment, education, and counseling to prevent STDs. They recommend that all sexually active adolescents and adults with an STD diagnosis or risk factors receive prevention counseling. The guidelines also address the use of condoms, pre-exposure vaccination for HPV, HAV, and HBV, and the importance of screening and treatment for HIV and other STDs in pregnant women. They highlight the role of male and female condoms in preventing STD transmission and the importance of consistent and correct use. The guidelines also discuss the use of antiretroviral therapy in HIV-positive individuals to prevent transmission to partners, the use of pre-exposure prophylaxis (PrEP) for HIV prevention, and the importance of partner services in identifying and treating sex partners of infected individuals. They emphasize the need for accurate and timely reporting of STDs to public health authorities and the importance of confidentiality in reporting. The guidelines also address special populations, including pregnant women, and recommend screening for HIV, syphilis, hepatitis B, and chlamydia. They emphasize the importance of testing and treatment for HIV in pregnant women to prevent perinatal transmission. The guidelines also discuss the use of expedited partner therapy (EPT) for treating sex partners of individuals diagnosed with chlamydia or gonorrhea. They highlight the importance of counseling and education for individuals at risk for STDs and the need for healthcare providers to follow state and local reporting requirements for STDs.The 2015 CDC Sexually Transmitted Diseases (STD) Treatment Guidelines update the 2010 guidelines to address new evidence and clinical practices. These guidelines aim to assist healthcare providers in the prevention and treatment of STDs. They cover alternative treatment regimens for gonorrhea, nucleic acid amplification tests for trichomoniasis, alternative treatments for genital warts, the role of Mycoplasma genitalium in urethritis, updated HPV vaccine recommendations, management of transgender individuals, annual hepatitis C testing for HIV-positive persons, updated diagnostic evaluation for urethritis, and retesting for repeat infections. The guidelines emphasize treatment but also include prevention strategies and diagnostic recommendations. The guidelines were developed by CDC staff and an independent workgroup of experts in STD management. They reviewed the latest literature, focusing on four outcomes of STD therapy: microbiologic eradication, symptom relief, prevention of complications, and transmission prevention. The workgroup evaluated the quality of evidence and rated recommendations using the USPSTF system. The guidelines are applicable in various healthcare settings and are intended for use by healthcare providers to guide clinical decisions. The guidelines emphasize the importance of accurate risk assessment, education, and counseling to prevent STDs. They recommend that all sexually active adolescents and adults with an STD diagnosis or risk factors receive prevention counseling. The guidelines also address the use of condoms, pre-exposure vaccination for HPV, HAV, and HBV, and the importance of screening and treatment for HIV and other STDs in pregnant women. They highlight the role of male and female condoms in preventing STD transmission and the importance of consistent and correct use. The guidelines also discuss the use of antiretroviral therapy in HIV-positive individuals to prevent transmission to partners, the use of pre-exposure prophylaxis (PrEP) for HIV prevention, and the importance of partner services in identifying and treating sex partners of infected individuals. They emphasize the need for accurate and timely reporting of STDs to public health authorities and the importance of confidentiality in reporting. The guidelines also address special populations, including pregnant women, and recommend screening for HIV, syphilis, hepatitis B, and chlamydia. They emphasize the importance of testing and treatment for HIV in pregnant women to prevent perinatal transmission. The guidelines also discuss the use of expedited partner therapy (EPT) for treating sex partners of individuals diagnosed with chlamydia or gonorrhea. They highlight the importance of counseling and education for individuals at risk for STDs and the need for healthcare providers to follow state and local reporting requirements for STDs.