The study evaluates the short-term and long-term effects of PM10 particulate matter on cardiovascular disease (CVD) mortality in Andimeshk City, Iran, using the AirQ+ software. The research focuses on the year 2022-2023, with data collected from the Environmental Department of Khuzestan and the Iranian Statistics Centre. The results show that PM10 concentrations were generally high, with only 8 days within the year exceeding the standard. The lowest concentration was recorded on January 9 (14.19 μg/m³), while the highest was on November 6 (5634.61 μg/m³). The AirQ+ model indicates that short-term exposure to PM10 is associated with a 39.31% attributable proportion and 43 deaths, while long-term exposure is associated with a 5.6% attributable proportion and 11 CVD deaths. The study concludes that Andimeshk is a polluted city, and the proximity to Iraq and Saudi Arabia, which have dry areas and frequent dust storms, is a significant contributor to air pollution. To mitigate the health effects of PM10, personal protective equipment and reduced daily activities on dusty days are recommended.The study evaluates the short-term and long-term effects of PM10 particulate matter on cardiovascular disease (CVD) mortality in Andimeshk City, Iran, using the AirQ+ software. The research focuses on the year 2022-2023, with data collected from the Environmental Department of Khuzestan and the Iranian Statistics Centre. The results show that PM10 concentrations were generally high, with only 8 days within the year exceeding the standard. The lowest concentration was recorded on January 9 (14.19 μg/m³), while the highest was on November 6 (5634.61 μg/m³). The AirQ+ model indicates that short-term exposure to PM10 is associated with a 39.31% attributable proportion and 43 deaths, while long-term exposure is associated with a 5.6% attributable proportion and 11 CVD deaths. The study concludes that Andimeshk is a polluted city, and the proximity to Iraq and Saudi Arabia, which have dry areas and frequent dust storms, is a significant contributor to air pollution. To mitigate the health effects of PM10, personal protective equipment and reduced daily activities on dusty days are recommended.