The article discusses the use of silk, particularly from the silkworm *Bombyx mori*, as a biomaterial in biomedical applications, focusing on its mechanical properties, biocompatibility, and potential for tissue engineering. Silk has been used as a suture material for centuries due to its unique mechanical properties, but recent studies have highlighted biocompatibility issues caused by residual sericin, a glue-like protein. Well-defined silkworm silk fibers and films show comparable biocompatibility to other commonly used biomaterials like polylactic acid and collagen. The article also explores the potential of silk in tissue engineering, particularly for bone and ligament formation, and the development of silk-based scaffolds. Despite some concerns about foreign body response and degradation, silk's mechanical properties, biodegradability, and ability to support cell growth make it a promising biomaterial. The article concludes by emphasizing the need for standardized guidelines and further research to fully capitalize on the potential of silk-based biomaterials.The article discusses the use of silk, particularly from the silkworm *Bombyx mori*, as a biomaterial in biomedical applications, focusing on its mechanical properties, biocompatibility, and potential for tissue engineering. Silk has been used as a suture material for centuries due to its unique mechanical properties, but recent studies have highlighted biocompatibility issues caused by residual sericin, a glue-like protein. Well-defined silkworm silk fibers and films show comparable biocompatibility to other commonly used biomaterials like polylactic acid and collagen. The article also explores the potential of silk in tissue engineering, particularly for bone and ligament formation, and the development of silk-based scaffolds. Despite some concerns about foreign body response and degradation, silk's mechanical properties, biodegradability, and ability to support cell growth make it a promising biomaterial. The article concludes by emphasizing the need for standardized guidelines and further research to fully capitalize on the potential of silk-based biomaterials.