The study introduces a novel silk fibroin hydrogel adhesive, S-PIL10, designed to repair meniscus tears. S-PIL10 is composed of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid (PIL) and loaded with the growth factor TGF-β1. The PIL enhances the wet adhesion, swelling resistance, and anti-fatigue capabilities of the adhesive compared to pure silk fibroin gel. Additionally, S-PIL10 scavenges reactive oxygen species (ROS) to improve the inflammatory microenvironment and continuously releases TGF-β1 to promote cell recruitment and defect edge bridging. In vivo rabbit models demonstrate that S-PIL10 enables seamless and dense reconstruction of torn meniscus, providing a promising strategy for preclinical research in meniscus tear repair. The study highlights the potential of this adhesive as a revolutionary treatment for meniscus tears, offering a novel approach to address the challenges of current surgical methods.The study introduces a novel silk fibroin hydrogel adhesive, S-PIL10, designed to repair meniscus tears. S-PIL10 is composed of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid (PIL) and loaded with the growth factor TGF-β1. The PIL enhances the wet adhesion, swelling resistance, and anti-fatigue capabilities of the adhesive compared to pure silk fibroin gel. Additionally, S-PIL10 scavenges reactive oxygen species (ROS) to improve the inflammatory microenvironment and continuously releases TGF-β1 to promote cell recruitment and defect edge bridging. In vivo rabbit models demonstrate that S-PIL10 enables seamless and dense reconstruction of torn meniscus, providing a promising strategy for preclinical research in meniscus tear repair. The study highlights the potential of this adhesive as a revolutionary treatment for meniscus tears, offering a novel approach to address the challenges of current surgical methods.